POTEE_HUMAN
ID POTEE_HUMAN Reviewed; 1075 AA.
AC Q6S8J3; Q6S8J4; Q6S8J5; Q6S8J8;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=POTE ankyrin domain family member E;
DE AltName: Full=ANKRD26-like family C member 1A;
DE AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 2;
DE Short=POTE-2;
GN Name=POTEE; Synonyms=A26C1A, POTE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-712 (ISOFORMS 1; 2 AND 3).
RC TISSUE=Prostate;
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=POTE2A;
CC IsoId=Q6S8J3-1; Sequence=Displayed;
CC Name=2; Synonyms=POTE2B;
CC IsoId=Q6S8J3-2; Sequence=VSP_011969, VSP_011972, VSP_011973;
CC Name=3; Synonyms=POTE2C, POTE2D;
CC IsoId=Q6S8J3-3; Sequence=VSP_011970, VSP_011971;
CC -!- SIMILARITY: In the N-terminal section; belongs to the POTE family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the actin family.
CC {ECO:0000305}.
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DR EMBL; AC131180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY462868; AAS58862.1; -; mRNA.
DR EMBL; AY462871; AAS58865.1; -; mRNA.
DR EMBL; AY462872; AAS58866.1; -; mRNA.
DR EMBL; AY462873; AAS58867.1; -; mRNA.
DR CCDS; CCDS46414.1; -. [Q6S8J3-1]
DR RefSeq; NP_001077007.1; NM_001083538.1. [Q6S8J3-1]
DR RefSeq; XP_016859650.1; XM_017004161.1. [Q6S8J3-1]
DR AlphaFoldDB; Q6S8J3; -.
DR SMR; Q6S8J3; -.
DR BioGRID; 138656; 130.
DR IntAct; Q6S8J3; 33.
DR MINT; Q6S8J3; -.
DR STRING; 9606.ENSP00000439189; -.
DR GlyGen; Q6S8J3; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q6S8J3; -.
DR MetOSite; Q6S8J3; -.
DR PhosphoSitePlus; Q6S8J3; -.
DR SwissPalm; Q6S8J3; -.
DR BioMuta; POTEE; -.
DR DMDM; 166898073; -.
DR EPD; Q6S8J3; -.
DR jPOST; Q6S8J3; -.
DR MassIVE; Q6S8J3; -.
DR MaxQB; Q6S8J3; -.
DR PaxDb; Q6S8J3; -.
DR PeptideAtlas; Q6S8J3; -.
DR PRIDE; Q6S8J3; -.
DR TopDownProteomics; Q6S8J3-1; -. [Q6S8J3-1]
DR Antibodypedia; 56140; 75 antibodies from 17 providers.
DR DNASU; 445582; -.
DR Ensembl; ENST00000356920.9; ENSP00000439189.1; ENSG00000188219.16. [Q6S8J3-1]
DR Ensembl; ENST00000358087.9; ENSP00000443049.1; ENSG00000188219.16. [Q6S8J3-2]
DR Ensembl; ENST00000514256.5; ENSP00000477649.1; ENSG00000188219.16. [Q6S8J3-3]
DR Ensembl; ENST00000626191.1; ENSP00000485683.1; ENSG00000188219.16. [Q6S8J3-3]
DR Ensembl; ENST00000683005.1; ENSP00000507284.1; ENSG00000188219.16. [Q6S8J3-1]
DR GeneID; 445582; -.
DR KEGG; hsa:445582; -.
DR MANE-Select; ENST00000683005.1; ENSP00000507284.1; NM_001083538.3; NP_001077007.1.
DR UCSC; uc002tsn.3; human. [Q6S8J3-1]
DR CTD; 445582; -.
DR DisGeNET; 445582; -.
DR GeneCards; POTEE; -.
DR HGNC; HGNC:33895; POTEE.
DR HPA; ENSG00000188219; Group enriched (brain, testis).
DR MIM; 608914; gene.
DR neXtProt; NX_Q6S8J3; -.
DR OpenTargets; ENSG00000188219; -.
DR PharmGKB; PA164724783; -.
DR VEuPathDB; HostDB:ENSG00000188219; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_010163_0_0_1; -.
DR InParanoid; Q6S8J3; -.
DR OMA; NPICELL; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; Q6S8J3; -.
DR PathwayCommons; Q6S8J3; -.
DR Reactome; R-HSA-9035034; RHOF GTPase cycle.
DR SignaLink; Q6S8J3; -.
DR BioGRID-ORCS; 445582; 52 hits in 985 CRISPR screens.
DR ChiTaRS; POTEE; human.
DR GenomeRNAi; 445582; -.
DR Pharos; Q6S8J3; Tbio.
DR PRO; PR:Q6S8J3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6S8J3; protein.
DR Bgee; ENSG00000188219; Expressed in testis and 10 other tissues.
DR ExpressionAtlas; Q6S8J3; baseline and differential.
DR GO; GO:0072562; C:blood microparticle; HDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB.
DR GO; GO:0021762; P:substantia nigra development; HEP:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1075
FT /note="POTE ankyrin domain family member E"
FT /id="PRO_0000066914"
FT REPEAT 172..201
FT /note="ANK 1"
FT REPEAT 205..234
FT /note="ANK 2"
FT REPEAT 238..267
FT /note="ANK 3"
FT REPEAT 271..300
FT /note="ANK 4"
FT REPEAT 304..333
FT /note="ANK 5"
FT REGION 369..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..1075
FT /note="Actin-like"
FT COILED 399..435
FT /evidence="ECO:0000255"
FT COILED 642..698
FT /evidence="ECO:0000255"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 212
FT /note="K -> KVCSSQLYQHE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011969"
FT VAR_SEQ 376
FT /note="E -> G (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011970"
FT VAR_SEQ 377..1075
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011971"
FT VAR_SEQ 377..384
FT /note="QELKLTSE -> NVSRTRNK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011972"
FT VAR_SEQ 385..1075
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011973"
FT CONFLICT 346
FT /note="V -> G (in Ref. 2; AAS58867)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="E -> D (in Ref. 2; AAS58865)"
FT /evidence="ECO:0000305"
FT CONFLICT 546
FT /note="G -> R (in Ref. 2; AAS58865)"
FT /evidence="ECO:0000305"
FT CONFLICT 563
FT /note="G -> A (in Ref. 2; AAS58865)"
FT /evidence="ECO:0000305"
FT CONFLICT 578
FT /note="P -> L (in Ref. 2; AAS58865)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1075 AA; 121363 MW; 581F842CDDC13EFC CRC64;
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD DSAMKTLRSK
MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK WCCHCFPCCR GSGKSKVGAW
GDYDDSAFME PRYHVRGEDL DKLHRAAWWG KVPRKDLIVM LRDTDVNKKD KQKRTALHLA
SANGNSEVVK LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN
TTLHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH HVICQLLSDY
KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK MSQELEINKD GDREVEEEMK
KHESNNVGLL ENLTNGVTAG NGDNGLIPQR KSRTPENQQF PDNESEEYHR ICELLSDYKE
KQMPKYSSEN SNPEQDLKLT SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE
EMKKHGSTHV GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST LREEIAMLRL
ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT MDDDTAVLVI DNGSGMCKAG
FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK ESYVGKEAQS KRGILTLKYP MEHGIITNWD
DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP
SLYTSGRTTG IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI GNERFRCPEA
LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS GGTTMYPGMA HRMQKEIAAL
APSMMKIRII APPKRKYSVW VGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF
