POTEG_HUMAN
ID POTEG_HUMAN Reviewed; 508 AA.
AC Q6S5H5; A1L153; A6NMI9; Q6S5H6; Q6S8J2;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 5.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=POTE ankyrin domain family member G;
DE AltName: Full=ANKRD26-like family C member 2;
DE AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 14;
DE Short=POTE-14;
GN Name=POTEG; Synonyms=A26C2, POTE14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Prostate;
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-458 (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3; Synonyms=POTE14A;
CC IsoId=Q6S5H5-3; Sequence=Displayed;
CC Name=2; Synonyms=POTE14C;
CC IsoId=Q6S5H5-2; Sequence=VSP_040057;
CC Name=1; Synonyms=POTE14B;
CC IsoId=Q6S5H5-4; Sequence=VSP_040056;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS58870.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY462874; AAS58868.1; -; mRNA.
DR EMBL; AY465171; AAS58870.1; ALT_FRAME; mRNA.
DR EMBL; AY465172; AAS58871.1; -; mRNA.
DR EMBL; AL512624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127623; AAI27624.1; -; mRNA.
DR CCDS; CCDS73610.1; -. [Q6S5H5-3]
DR RefSeq; NP_001005356.1; NM_001005356.2. [Q6S5H5-3]
DR AlphaFoldDB; Q6S5H5; -.
DR SMR; Q6S5H5; -.
DR BioGRID; 135711; 11.
DR STRING; 9606.ENSP00000450853; -.
DR iPTMnet; Q6S5H5; -.
DR PhosphoSitePlus; Q6S5H5; -.
DR BioMuta; POTEG; -.
DR DMDM; 313104320; -.
DR MassIVE; Q6S5H5; -.
DR MaxQB; Q6S5H5; -.
DR PaxDb; Q6S5H5; -.
DR PeptideAtlas; Q6S5H5; -.
DR PRIDE; Q6S5H5; -.
DR ProteomicsDB; 67339; -. [Q6S5H5-3]
DR ProteomicsDB; 67340; -. [Q6S5H5-2]
DR Antibodypedia; 58505; 139 antibodies from 17 providers.
DR DNASU; 404785; -.
DR Ensembl; ENST00000547722.1; ENSP00000450807.1; ENSG00000187537.13. [Q6S5H5-4]
DR Ensembl; ENST00000547848.5; ENSP00000450853.2; ENSG00000187537.13. [Q6S5H5-3]
DR Ensembl; ENST00000622767.4; ENSP00000482662.1; ENSG00000187537.13. [Q6S5H5-2]
DR GeneID; 404785; -.
DR KEGG; hsa:404785; -.
DR MANE-Select; ENST00000547848.5; ENSP00000450853.2; NM_001005356.3; NP_001005356.1.
DR UCSC; uc001vuz.3; human. [Q6S5H5-3]
DR CTD; 404785; -.
DR DisGeNET; 404785; -.
DR GeneCards; POTEG; -.
DR HGNC; HGNC:33896; POTEG.
DR HPA; ENSG00000187537; Tissue enhanced (prostate).
DR MIM; 608916; gene.
DR neXtProt; NX_Q6S5H5; -.
DR OpenTargets; ENSG00000187537; -.
DR PharmGKB; PA164724853; -.
DR VEuPathDB; HostDB:ENSG00000187537; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR InParanoid; Q6S5H5; -.
DR OMA; HDDSSMK; -.
DR OrthoDB; 1559479at2759; -.
DR PhylomeDB; Q6S5H5; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; Q6S5H5; -.
DR BioGRID-ORCS; 404785; 496 hits in 968 CRISPR screens.
DR ChiTaRS; POTEG; human.
DR GenomeRNAi; 404785; -.
DR Pharos; Q6S5H5; Tdark.
DR PRO; PR:Q6S5H5; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6S5H5; protein.
DR Bgee; ENSG00000187537; Expressed in prostate gland and 6 other tissues.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..508
FT /note="POTE ankyrin domain family member G"
FT /id="PRO_0000066916"
FT REPEAT 172..201
FT /note="ANK 1"
FT REPEAT 205..234
FT /note="ANK 2"
FT REPEAT 238..267
FT /note="ANK 3"
FT REPEAT 271..300
FT /note="ANK 4"
FT REPEAT 304..333
FT /note="ANK 5"
FT REGION 367..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 271..507
FT /note="HGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVS
FT LLLEQNIDVSSQDLSGQTAREYAVSSHHNVICQLLSDYKEKQMLKVSSENSNPEQDLKL
FT TSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHGSTHMGFPENLPNGATAD
FT NGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEEQNTGILQDEILIHEEK
FT QIEVAENE -> IESHSVSQAGVQWCDHSSLQPRPPEAQMVLQPQPQLFFSFFLFIFIF
FT IFIF (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_040056"
FT VAR_SEQ 470..508
FT /note="SDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF -> RDFSGHPNF
FT PTTLPIKQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_040057"
FT CONFLICT 33
FT /note="P -> A (in Ref. 1; AAS58870)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="R -> C (in Ref. 1; AAS58870)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="S -> G (in Ref. 1; AAS58870/AAS58871)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="I -> V (in Ref. 1; AAS58870)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="R -> Q (in Ref. 1; AAS58870/AAS58871 and 3;
FT AAI27624)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="A -> T (in Ref. 1; AAS58871)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="H -> R (in Ref. 1; AAS58868/AAS58871)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="M -> I (in Ref. 1; AAS58868)"
FT /evidence="ECO:0000305"
FT CONFLICT 379
FT /note="L -> S (in Ref. 3; AAI27624)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="P -> T (in Ref. 1; AAS58871 and 3; AAI27624)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 57096 MW; D7381307809863A3 CRC64;
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK
MGKWCRHCFP WCRGSSKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA
SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCREDE CALMLLEHGT DPNIPDEYGN
TALHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH NVICQLLSDY
KEKQMLKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE MSQEPEINKG GDRKVEEEMK
KHGSTHMGFP ENLPNGATAD NGDDGLIPPR KSRTPESQQF PDTENEQYHS DEQNDTQKQL
SEEQNTGILQ DEILIHEEKQ IEVAENEF
