POTEH_HUMAN
ID POTEH_HUMAN Reviewed; 545 AA.
AC Q6S545; A2CEK4; A6NCI1; A9Z1W0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=POTE ankyrin domain family member H;
DE AltName: Full=ANKRD26-like family C member 3;
DE AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 22;
DE Short=POTE-22;
GN Name=POTEH; Synonyms=A26C3, ACTBL1, POTE22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Prostate;
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6S545-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6S545-2; Sequence=VSP_039738;
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
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DR EMBL; CR545463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY466021; AAS58873.1; -; mRNA.
DR CCDS; CCDS74808.1; -. [Q6S545-1]
DR RefSeq; NP_001129685.1; NM_001136213.1. [Q6S545-1]
DR AlphaFoldDB; Q6S545; -.
DR SMR; Q6S545; -.
DR BioGRID; 117283; 1.
DR IntAct; Q6S545; 1.
DR STRING; 9606.ENSP00000340610; -.
DR iPTMnet; Q6S545; -.
DR PhosphoSitePlus; Q6S545; -.
DR BioMuta; POTEH; -.
DR DMDM; 166898062; -.
DR MassIVE; Q6S545; -.
DR MaxQB; Q6S545; -.
DR PaxDb; Q6S545; -.
DR PeptideAtlas; Q6S545; -.
DR PRIDE; Q6S545; -.
DR ProteomicsDB; 67334; -. [Q6S545-1]
DR Antibodypedia; 22601; 116 antibodies from 25 providers.
DR DNASU; 23784; -.
DR Ensembl; ENST00000343518.11; ENSP00000340610.6; ENSG00000198062.16. [Q6S545-1]
DR GeneID; 23784; -.
DR KEGG; hsa:23784; -.
DR MANE-Select; ENST00000343518.11; ENSP00000340610.6; NM_001136213.1; NP_001129685.1.
DR UCSC; uc010gqp.3; human. [Q6S545-1]
DR CTD; 23784; -.
DR DisGeNET; 23784; -.
DR GeneCards; POTEH; -.
DR HGNC; HGNC:133; POTEH.
DR HPA; ENSG00000198062; Group enriched (prostate, testis).
DR MIM; 608913; gene.
DR neXtProt; NX_Q6S545; -.
DR OpenTargets; ENSG00000198062; -.
DR PharmGKB; PA24458; -.
DR VEuPathDB; HostDB:ENSG00000198062; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR InParanoid; Q6S545; -.
DR OrthoDB; 1559479at2759; -.
DR PhylomeDB; Q6S545; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; Q6S545; -.
DR SignaLink; Q6S545; -.
DR BioGRID-ORCS; 23784; 32 hits in 624 CRISPR screens.
DR GenomeRNAi; 23784; -.
DR Pharos; Q6S545; Tdark.
DR PRO; PR:Q6S545; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6S545; protein.
DR Bgee; ENSG00000198062; Expressed in prostate gland and 7 other tissues.
DR ExpressionAtlas; Q6S545; baseline and differential.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..545
FT /note="POTE ankyrin domain family member H"
FT /id="PRO_0000066918"
FT REPEAT 180..208
FT /note="ANK 1"
FT REPEAT 209..238
FT /note="ANK 2"
FT REPEAT 242..271
FT /note="ANK 3"
FT REPEAT 275..304
FT /note="ANK 4"
FT REPEAT 308..337
FT /note="ANK 5"
FT REPEAT 341..370
FT /note="ANK 6"
FT REPEAT 374..404
FT /note="ANK 7"
FT REGION 406..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 289..545
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_039738"
FT CONFLICT 238
FT /note="I -> V (in Ref. 2; AAS58873)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 545 AA; 60965 MW; 35F2B1C6D670B181 CRC64;
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK
MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS
GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL
HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD
NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA
DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV CCGSASIVSL
LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK QILKVSSENS NPEQDLKLTS
EEESQRLKGS ENSQPEEMSQ EPEINKGGDR KVEEEMKKHG STHMGFPENL TNGATADNGD
DGLIPPRKSR TPESQQFPDT ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV
AENEF
