POTEI_HUMAN
ID POTEI_HUMAN Reviewed; 1075 AA.
AC P0CG38;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=POTE ankyrin domain family member I;
GN Name=POTEI;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SIMILARITY: In the N-terminal section; belongs to the POTE family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the actin family.
CC {ECO:0000305}.
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DR EMBL; AC013269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59431.1; -.
DR RefSeq; NP_001264335.1; NM_001277406.1.
DR AlphaFoldDB; P0CG38; -.
DR SMR; P0CG38; -.
DR BioGRID; 575653; 96.
DR IntAct; P0CG38; 36.
DR MINT; P0CG38; -.
DR STRING; 9606.ENSP00000392718; -.
DR GlyGen; P0CG38; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P0CG38; -.
DR MetOSite; P0CG38; -.
DR PhosphoSitePlus; P0CG38; -.
DR SwissPalm; P0CG38; -.
DR BioMuta; POTEI; -.
DR DMDM; 300681051; -.
DR EPD; P0CG38; -.
DR jPOST; P0CG38; -.
DR MassIVE; P0CG38; -.
DR MaxQB; P0CG38; -.
DR PaxDb; P0CG38; -.
DR PeptideAtlas; P0CG38; -.
DR PRIDE; P0CG38; -.
DR ProteomicsDB; 52468; -.
DR TopDownProteomics; P0CG38; -.
DR DNASU; 653269; -.
DR Ensembl; ENST00000451531.7; ENSP00000392718.2; ENSG00000196834.14.
DR GeneID; 653269; -.
DR KEGG; hsa:653269; -.
DR MANE-Select; ENST00000451531.7; ENSP00000392718.2; NM_001277406.2; NP_001264335.1.
DR UCSC; uc031rpa.2; human.
DR CTD; 653269; -.
DR GeneCards; POTEI; -.
DR HGNC; HGNC:37093; POTEI.
DR HPA; ENSG00000196834; Group enriched (brain, prostate, testis).
DR neXtProt; NX_P0CG38; -.
DR OpenTargets; ENSG00000196834; -.
DR PharmGKB; PA165697301; -.
DR VEuPathDB; HostDB:ENSG00000196834; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_010163_0_0_1; -.
DR InParanoid; P0CG38; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P0CG38; -.
DR TreeFam; TF354237; -.
DR PathwayCommons; P0CG38; -.
DR SignaLink; P0CG38; -.
DR BioGRID-ORCS; 653269; 223 hits in 955 CRISPR screens.
DR ChiTaRS; POTEI; human.
DR GenomeRNAi; 653269; -.
DR Pharos; P0CG38; Tdark.
DR PRO; PR:P0CG38; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0CG38; protein.
DR Bgee; ENSG00000196834; Expressed in testis and 22 other tissues.
DR ExpressionAtlas; P0CG38; baseline and differential.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 3: Inferred from homology;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1075
FT /note="POTE ankyrin domain family member I"
FT /id="PRO_0000395413"
FT REPEAT 172..201
FT /note="ANK 1"
FT REPEAT 205..234
FT /note="ANK 2"
FT REPEAT 238..267
FT /note="ANK 3"
FT REPEAT 271..300
FT /note="ANK 4"
FT REPEAT 304..333
FT /note="ANK 5"
FT REGION 369..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..1075
FT /note="Actin-like"
FT COILED 413..436
FT /evidence="ECO:0000255"
FT COILED 642..698
FT /evidence="ECO:0000255"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 121282 MW; B85717179453DCBA CRC64;
MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD DSTMKTLRSK
MGKWCCHCFP CCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW
GDYDDSAFVE PRYHVRREDL DKLHRAAWWG KVARKDLIVM LRDTDVNKQD KQKRTALHLA
SANGNSGVVK LLLDRRCQLN VLDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN
TTLHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH HVICQLLSDY
KEKQMLKISS ENSNPEQDLK LTSEEESQRF KGSENSQPEK MSQEPEINKD GDREVEEEMK
KHESNNVGLL ENLSNGVTAG NGDDGLIPQR KSRTPENQQF PDNESEEYHR ICELVSDYKE
KQMPKYSSEN SNPEQDLKLT SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE
EMKKHGSTHV GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDFLHENST LREEIAMLRL
ELDTMKHQSQ LRKKKYLEDI ESVKKKNDNL LKALQLNELT MDDDTAVLVI DNGSGMCKAG
FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK ESYVGKEAQS KRGILTLKYP MEHGIITNWD
DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAML
SLYTSGRTTG IVMDSGDGVT HTVPIYDGNA LPHATLRLDL AGRELTDYLM KILTERGYRF
TTMAEREIVR DIKEKLCYVA LDFEQEMAMA ASSSSLEKSY ELPDGQVITI GNEWFRCPEA
LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS GGTTMYPGMA HRMQKEIAAL
APSMLKIRII APPKRKYSVW VGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF
