POTEJ_HUMAN
ID POTEJ_HUMAN Reviewed; 1038 AA.
AC P0CG39;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=POTE ankyrin domain family member J;
GN Name=POTEJ;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SIMILARITY: In the N-terminal section; belongs to the POTE family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the actin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC140481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59432.1; -.
DR RefSeq; NP_001264012.1; NM_001277083.1.
DR AlphaFoldDB; P0CG39; -.
DR SMR; P0CG39; -.
DR BioGRID; 576066; 43.
DR IntAct; P0CG39; 7.
DR MINT; P0CG39; -.
DR STRING; 9606.ENSP00000387176; -.
DR iPTMnet; P0CG39; -.
DR PhosphoSitePlus; P0CG39; -.
DR SwissPalm; P0CG39; -.
DR BioMuta; POTEJ; -.
DR DMDM; 300681052; -.
DR EPD; P0CG39; -.
DR jPOST; P0CG39; -.
DR MassIVE; P0CG39; -.
DR MaxQB; P0CG39; -.
DR PaxDb; P0CG39; -.
DR PeptideAtlas; P0CG39; -.
DR PRIDE; P0CG39; -.
DR ProteomicsDB; 52469; -.
DR TopDownProteomics; P0CG39; -.
DR Antibodypedia; 68638; 14 antibodies from 4 providers.
DR DNASU; 653781; -.
DR Ensembl; ENST00000409602.2; ENSP00000387176.1; ENSG00000222038.4.
DR GeneID; 653781; -.
DR KEGG; hsa:653781; -.
DR MANE-Select; ENST00000409602.2; ENSP00000387176.1; NM_001277083.2; NP_001264012.1.
DR UCSC; uc021vor.3; human.
DR CTD; 653781; -.
DR GeneCards; POTEJ; -.
DR HGNC; HGNC:37094; POTEJ.
DR HPA; ENSG00000222038; Not detected.
DR neXtProt; NX_P0CG39; -.
DR OpenTargets; ENSG00000222038; -.
DR PharmGKB; PA165697368; -.
DR VEuPathDB; HostDB:ENSG00000222038; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_010163_0_0_1; -.
DR InParanoid; P0CG39; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P0CG39; -.
DR TreeFam; TF354237; -.
DR PathwayCommons; P0CG39; -.
DR SignaLink; P0CG39; -.
DR BioGRID-ORCS; 653781; 224 hits in 976 CRISPR screens.
DR ChiTaRS; POTEJ; human.
DR GenomeRNAi; 653781; -.
DR Pharos; P0CG39; Tdark.
DR PRO; PR:P0CG39; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0CG39; protein.
DR Bgee; ENSG00000222038; Expressed in cortical plate and 10 other tissues.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 3: Inferred from homology;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1038
FT /note="POTE ankyrin domain family member J"
FT /id="PRO_0000395414"
FT REPEAT 135..164
FT /note="ANK 1"
FT REPEAT 168..197
FT /note="ANK 2"
FT REPEAT 201..230
FT /note="ANK 3"
FT REPEAT 234..263
FT /note="ANK 4"
FT REPEAT 267..296
FT /note="ANK 5"
FT REGION 332..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..1038
FT /note="Actin-like"
FT COILED 605..661
FT /evidence="ECO:0000255"
FT COMPBIAS 341..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 117390 MW; FFDFF97D149A0899 CRC64;
MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD DSTMKTLRSK
MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR EDLDKLHRAA WWGKVARKDL
IVMLRDTDVN KQDKQKRTAL HLASANGNSG VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ
EDECALMLLE HGTDPNIPDE YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL
LGVHEQKQQV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS
GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRFKGSENSQ
PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV TAGNGDDGLI PQRKSRTPEN
QQFPDNESEE YHRICELVSD YKEKQMPKYS SENSNPEQDL KLTSEEESQR LKGSENGQPE
KRSQEPEINK DGDRELENFM AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT
PESQQFPDTE NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS
CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN DNLLKALQLN
ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC PRQQGMMGGM HQKESYVGKE
AQSKRGILTL KYPMEHGIIT NWDDMEKIWH HTFYNELRVA PEEHPILLTE APLNPKANRE
KMTQIMFETF NTPAMYVAIQ AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR
LDLAGRELTD YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE
KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV DIRKDLYTNT
VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY SVWVGGSILA SLSTFQQMWI
SKQEYDESGP SIVHRKCF
