ID   POTEM_HUMAN             Reviewed;         508 AA.
AC   A6NI47;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative POTE ankyrin domain family member M;
GN   Name=POTEM;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
CC   -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL589182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS73609.1; -.
DR   RefSeq; NP_001138914.1; NM_001145442.1.
DR   AlphaFoldDB; A6NI47; -.
DR   SMR; A6NI47; -.
DR   BioGRID; 534980; 1.
DR   STRING; 9606.ENSP00000448062; -.
DR   iPTMnet; A6NI47; -.
DR   PhosphoSitePlus; A6NI47; -.
DR   BioMuta; POTEM; -.
DR   MassIVE; A6NI47; -.
DR   MaxQB; A6NI47; -.
DR   PaxDb; A6NI47; -.
DR   PeptideAtlas; A6NI47; -.
DR   PRIDE; A6NI47; -.
DR   Antibodypedia; 58500; 17 antibodies from 6 providers.
DR   DNASU; 641455; -.
DR   Ensembl; ENST00000547889.6; ENSP00000448062.2; ENSG00000222036.8.
DR   GeneID; 641455; -.
DR   KEGG; hsa:641455; -.
DR   MANE-Select; ENST00000547889.6; ENSP00000448062.2; NM_001145442.1; NP_001138914.1.
DR   CTD; 641455; -.
DR   DisGeNET; 641455; -.
DR   GeneCards; POTEM; -.
DR   HGNC; HGNC:37096; POTEM.
DR   HPA; ENSG00000222036; Tissue enriched (prostate).
DR   neXtProt; NX_A6NI47; -.
DR   OpenTargets; ENSG00000222036; -.
DR   PharmGKB; PA165479276; -.
DR   VEuPathDB; HostDB:ENSG00000222036; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000163068; -.
DR   HOGENOM; CLU_000134_9_2_1; -.
DR   InParanoid; A6NI47; -.
DR   OMA; DSHETYA; -.
DR   OrthoDB; 1559479at2759; -.
DR   PhylomeDB; A6NI47; -.
DR   TreeFam; TF337879; -.
DR   PathwayCommons; A6NI47; -.
DR   SignaLink; A6NI47; -.
DR   BioGRID-ORCS; 641455; 197 hits in 963 CRISPR screens.
DR   ChiTaRS; POTEM; human.
DR   GenomeRNAi; 641455; -.
DR   Pharos; A6NI47; Tdark.
DR   PRO; PR:A6NI47; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; A6NI47; protein.
DR   Bgee; ENSG00000222036; Expressed in buccal mucosa cell and 64 other tissues.
DR   ExpressionAtlas; A6NI47; baseline and differential.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   3: Inferred from homology;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..508
FT                   /note="Putative POTE ankyrin domain family member M"
FT                   /id="PRO_0000332150"
FT   REPEAT          172..201
FT                   /note="ANK 1"
FT   REPEAT          205..234
FT                   /note="ANK 2"
FT   REPEAT          238..267
FT                   /note="ANK 3"
FT   REPEAT          271..300
FT                   /note="ANK 4"
FT   REPEAT          304..333
FT                   /note="ANK 5"
FT   REGION          369..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..425
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  57067 MW;  786971B0BAFAC804 CRC64;
     MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK
     MGKWCRHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW
     GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA
     SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN
     TALHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
     LDRYGRTVLI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSRH NVICQLLSDY
     KEKQILKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE MSQEPEINKG GDRKVEEEMK
     KHGSTHMGFP ENLPNGATAD NGDDGLIPPR KSRTPESQQF PDTENEQYHS DEQNDTQKQL
     SEEQNTGILQ DEILIHEEKQ IEVAENEF