ID   POU1_DUGJA              Reviewed;         559 AA.
AC   P31370;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=POU domain protein 1;
DE            Short=DjPOU1;
GN   Name=POU1;
OS   Dugesia japonica (Planarian).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Dugesia.
OX   NCBI_TaxID=6161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8099480; DOI=10.1006/bbrc.1993.1571;
RA   Orii H., Agata K., Watanabe K.;
RT   "POU-domain genes in planarian Dugesia japonica: the structure and
RT   expression.";
RL   Biochem. Biophys. Res. Commun. 192:1395-1402(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family.
CC       {ECO:0000305}.
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DR   EMBL; D12924; BAA02308.1; -; mRNA.
DR   PIR; JQ2010; JQ2010.
DR   AlphaFoldDB; P31370; -.
DR   SMR; P31370; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..559
FT                   /note="POU domain protein 1"
FT                   /id="PRO_0000100783"
FT   DOMAIN          259..333
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        351..410
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   559 AA;  63999 MW;  E4161FE2A4CF2230 CRC64;
     MTQVSHIGSS HFNINSSIKT ALPLINSQYN SLVNESTISS NINLPFRLDA PSLFNGLPEE
     WGPTDAELST HSNVNYPGLT EATIDYKFCS TLNSYFDTNQ RFGNVPNDTY LMANSMAANI
     ENNSWHNSRY YFDGNHPLSQ WLPVPVNCWS NNNYIRDDFY DKSIQEEEFK SRSVLQTNEK
     NSTNVSSDIN HYKPLITDEN ENLKMTKPTH NLLNNDSINL CRFPQNEIIM PDLINAPSPT
     LTNNNLFYSC GDHRSGKTED LPSSDDLEQF AKMFKQRRIK LGYTQADVGL ALGTLYGNVF
     SQTTICRFEA LQLSFKNMCK LRPLLQKWLH EADSSSESPT NFDKISAQSR KRKKRTSIEA
     NVKSILESSF MKLSKPSAQD ISSLAEKLSL EKEVVRVWFC NRRQKEKRIT PSFDVNEQFD
     NEVSSTMPYS TLNDDRNEKT IKNSFENHEK LIKQTGETNH EQNNNSSVKR LKIRKEPDQI
     SINDENTSCR AESSGIVPDT HYRQECDNHS ICGYNIHDIH ESSVLMSDPV SFYPRSFFMK
     NNIYSNGTTP TLFDHSQMI