ID   POX18_CANTR             Reviewed;         127 AA.
AC   P22009;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Oleate-induced peroxisomal protein POX18;
DE            Short=PXP-18;
DE   AltName: Full=Lipid-transfer protein;
GN   Name=POX18;
OS   Candida tropicalis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-17.
RC   STRAIN=ATCC 20336 / pK233 / NCYC 997;
RX   PubMed=2470648; DOI=10.1016/0378-1119(89)90388-0;
RA   Szabo L.J., Small G.M., Lazarow P.B.;
RT   "The nucleotide sequence of POX18, a gene encoding a small oleate-inducible
RT   peroxisomal protein from Candida tropicalis.";
RL   Gene 75:119-126(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20336 / pK233 / NCYC 997;
RX   PubMed=2364939; DOI=10.1111/j.1432-1033.1990.tb15552.x;
RA   Tan H., Okazaki K., Kubota I., Kamiryo T., Utiyama H.;
RT   "A novel peroxisomal nonspecific lipid-transfer protein from Candida
RT   tropicalis. Gene structure, purification and possible role in beta-
RT   oxidation.";
RL   Eur. J. Biochem. 190:107-112(1990).
CC   -!- FUNCTION: Is involved in beta-oxidation of long-chain fatty acids. Its
CC       exact function is unknown, but possesses a nonspecific lipid-transfer
CC       activity, despite the absence of a cysteine residue thought to be
CC       essential for the activity of its mammalian counterparts.
CC   -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- INDUCTION: By alkanes or fatty acids; repressed by glucose.
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DR   EMBL; X53633; CAA37682.1; -; Genomic_DNA.
DR   EMBL; M24440; AAA56863.1; -; Genomic_DNA.
DR   PIR; JS0155; JS0155.
DR   AlphaFoldDB; P22009; -.
DR   SMR; P22009; -.
DR   VEuPathDB; FungiDB:CTMYA2_051240; -.
DR   VEuPathDB; FungiDB:CTRG_02171; -.
DR   UniPathway; UPA00199; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   InterPro; IPR039543; POX18/UbiT/NSL-TP1.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   PANTHER; PTHR10094; PTHR10094; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Lipid-binding; Peroxisome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2470648"
FT   CHAIN           2..127
FT                   /note="Oleate-induced peroxisomal protein POX18"
FT                   /id="PRO_0000058528"
FT   DOMAIN          14..119
FT                   /note="SCP2"
FT                   /evidence="ECO:0000255"
FT   REGION          33..41
FT                   /note="Hydrophobic"
FT   REGION          43..52
FT                   /note="Hydrophilic"
SQ   SEQUENCE   127 AA;  13806 MW;  942D99F56A4FAC00 CRC64;
     MSVEVDGFNA SPLFKELNDG LADKAKAQEA VKAVNAIIVI TLKNKEGKEQ SWVLDLKKDG
     TLAKVDGAAP KGDVQLILKD VDFVKLANNK VNGQKLFMNG KLKVKGNMMK ATAIEAVFKK
     LDPRPKL