POXA_PENO1
ID POXA_PENO1 Reviewed; 567 AA.
AC S7ZK48;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 1.
DT 03-AUG-2022, entry version 26.
DE RecName: Full=MFS-type tansporter poxA {ECO:0000303|PubMed:28365998};
DE AltName: Full=Oxaleimides biosynthesis cluster protein A {ECO:0000303|PubMed:28365998};
GN Name=poxA {ECO:0000303|PubMed:28365998}; ORFNames=PDE_04008;
OS Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=933388;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=114-2 / CGMCC 5302;
RX PubMed=23383313; DOI=10.1371/journal.pone.0055185;
RA Liu G., Zhang L., Wei X., Zou G., Qin Y., Ma L., Li J., Zheng H., Wang S.,
RA Wang C., Xun L., Zhao G.-P., Zhou Z., Qu Y.;
RT "Genomic and secretomic analyses reveal unique features of the
RT lignocellulolytic enzyme system of Penicillium decumbens.";
RL PLoS ONE 8:E55185-E55185(2013).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=28365998; DOI=10.1021/jacs.7b02432;
RA Sato M., Dander J.E., Sato C., Hung Y.S., Gao S.S., Tang M.C., Hang L.,
RA Winter J.M., Garg N.K., Watanabe K., Tang Y.;
RT "Collaborative Biosynthesis of Maleimide- and Succinimide-Containing
RT Natural Products by Fungal Polyketide Megasynthases.";
RL J. Am. Chem. Soc. 139:5317-5320(2017).
RN [3]
RP FUNCTION.
RX PubMed=32039410; DOI=10.1039/c9cc09590j;
RA Hantke V., Skellam E.J., Cox R.J.;
RT "Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization
RT during the biosynthesis of pyrichalasin H.";
RL Chem. Commun. (Camb.) 56:2925-2928(2020).
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of oxaleimides, cytotoxic compounds containing an
CC unusual disubstituted succinimide moiety.
CC {ECO:0000269|PubMed:28365998}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:28365998};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: Expression is positively regulated by the oxaleimides
CC biosynthesis cluster-specific transcription factor poxB.
CC {ECO:0000269|PubMed:28365998}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; KB644411; EPS29061.1; -; Genomic_DNA.
DR SMR; S7ZK48; -.
DR STRING; 933388.S7ZK48; -.
DR EnsemblFungi; EPS29061; EPS29061; PDE_04008.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_22_1_1; -.
DR OrthoDB; 1044694at2759; -.
DR PhylomeDB; S7ZK48; -.
DR Proteomes; UP000019376; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..567
FT /note="MFS-type tansporter poxA"
FT /id="PRO_0000453768"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 567 AA; 60410 MW; 60FA7696682AB8F1 CRC64;
MPASDRTSET GDVEKVTAAE TPKEVPASNA AESTALTGLP LYTVLVGLGL ALFLGAMDMA
MLGTAVPSIT STFHTTADIG WYGAAYPLTM SSIQLLAGKI YAQFPQKLVF LVFFGLFMLG
SLLCGVAVNS PMFIVGRATA GAGAAGVLSG TLAIVSAVVP LDKQSLILGL MMSLVGTAVV
LGPVISGLLT DHSTWRWCFY LNLPCGGVTL LALILFFRPP KRPTRTTPLS IPELIKKLDL
AGCLGFIPAV VMLLLALQWG GDGSKEHAWN SATIIGLFCG AGVSLILFLI WEHYQGDDAM
LPLKFFRDLT IIASCLYGFA LLGGYVVVGY FLPEWFQIIK GANPQSSAVM LLPNVITNFI
SKAVIGVIVN KTGYFNPWLF FGAAVLAIGS GLETNFHPST PRPNWIGYQI LQGAALGIIQ
APTLGVQVAL AKQKHLIPVA LSLVIFFQYF GSSIMLSISL TIFQNLLRPG LVSKAGMTEA
QVQQYVAAGN SEVRELTAQI DPSRLGVVLE VYNDAIAGVM WLSTAAALFG FLVSFGFPWK
SLKAQTEENK KEAAEEEEEV KVAAVEA
