POXB_PENO1
ID POXB_PENO1 Reviewed; 574 AA.
AC S8B3H6;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=C6 finger transcription factor poxB {ECO:0000303|PubMed:28365998};
DE AltName: Full=Oxaleimides biosynthesis cluster protein B {ECO:0000303|PubMed:28365998};
GN Name=poxB {ECO:0000303|PubMed:28365998}; ORFNames=PDE_04009;
OS Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=933388;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=114-2 / CGMCC 5302;
RX PubMed=23383313; DOI=10.1371/journal.pone.0055185;
RA Liu G., Zhang L., Wei X., Zou G., Qin Y., Ma L., Li J., Zheng H., Wang S.,
RA Wang C., Xun L., Zhao G.-P., Zhou Z., Qu Y.;
RT "Genomic and secretomic analyses reveal unique features of the
RT lignocellulolytic enzyme system of Penicillium decumbens.";
RL PLoS ONE 8:E55185-E55185(2013).
RN [2]
RP FUNCTION.
RX PubMed=28365998; DOI=10.1021/jacs.7b02432;
RA Sato M., Dander J.E., Sato C., Hung Y.S., Gao S.S., Tang M.C., Hang L.,
RA Winter J.M., Garg N.K., Watanabe K., Tang Y.;
RT "Collaborative Biosynthesis of Maleimide- and Succinimide-Containing
RT Natural Products by Fungal Polyketide Megasynthases.";
RL J. Am. Chem. Soc. 139:5317-5320(2017).
RN [3]
RP FUNCTION.
RX PubMed=32039410; DOI=10.1039/c9cc09590j;
RA Hantke V., Skellam E.J., Cox R.J.;
RT "Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization
RT during the biosynthesis of pyrichalasin H.";
RL Chem. Commun. (Camb.) 56:2925-2928(2020).
CC -!- FUNCTION: Transcription factor that positively regulates the expression
CC of the gene cluster that mediates the biosynthesis of oxaleimides,
CC cytotoxic compounds containing an unusual disubstituted succinimide
CC moiety. {ECO:0000269|PubMed:28365998}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB644411; EPS29062.1; -; Genomic_DNA.
DR SMR; S8B3H6; -.
DR EnsemblFungi; EPS29062; EPS29062; PDE_04009.
DR eggNOG; ENOG502SYRD; Eukaryota.
DR HOGENOM; CLU_494289_0_0_1; -.
DR OrthoDB; 1576792at2759; -.
DR PhylomeDB; S8B3H6; -.
DR Proteomes; UP000019376; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..574
FT /note="C6 finger transcription factor poxB"
FT /id="PRO_0000453770"
FT DNA_BIND 19..51
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 111..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 62081 MW; 26ADAF6C75999140 CRC64;
MSEAEPSVVV AEQCRRSACD RCRGQKLRCE RPVSNSSTTP CRRCLKAHVR CVTTAQPHRT
KPLSSLQYLH HTESNYDPHS ATVAGQLPVA AVAGLGDLDP SLLHMTGVQN PRRLSHSSSM
ANPVDSRPPG RTRRLSNPDH FLPHPPLHPN GVLDTDGTPL LDSIDHLPDM TASRGFGFSA
ALTPHSPSGS SDFFDYFRPM AEDNNRSPWM DAFTNLPPDH REGTPAGSNY RGSLTGENQF
RSSLQSSRGL NGFETPQRES RHREMDIVSI KNECIARMGK LNRGLLQDVG LVNSGKVAGT
LLFSQASRST YLEVEKGRKG GQNYVIGKML HSSKELLDIL KQLERCKSTL FPPGHTERTT
STADEVTTAM TETTTLNQTG SHAPSSPLGG NPLPPLSGPL SASASHSSSC ASSSSASAST
SGASLLSSST SAPSTSPAIS LQLDTTLTLL FLTGYTSVIQ LYEGVFSFIR DSVAANPSGS
NFLPTLPKLQ VDGFEVGSST RDLQICILLQ VSTHILNQIE ERLHAIRDRA EGHVPAALLD
TILDRSDPSQ RGAKGRELCR IVRDIKEHLK HYAE