ID   POXB_PENOX              Reviewed;         574 AA.
AC   A0A1W5T1T3;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=C6 finger transcription factor poxB {ECO:0000303|PubMed:28365998};
DE   AltName: Full=Oxaleimides biosynthesis cluster protein B {ECO:0000303|PubMed:28365998};
GN   Name=poxB {ECO:0000303|PubMed:28365998};
OS   Penicillium oxalicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=69781;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=K85;
RX   PubMed=28365998; DOI=10.1021/jacs.7b02432;
RA   Sato M., Dander J.E., Sato C., Hung Y.S., Gao S.S., Tang M.C., Hang L.,
RA   Winter J.M., Garg N.K., Watanabe K., Tang Y.;
RT   "Collaborative Biosynthesis of Maleimide- and Succinimide-Containing
RT   Natural Products by Fungal Polyketide Megasynthases.";
RL   J. Am. Chem. Soc. 139:5317-5320(2017).
RN   [2]
RP   FUNCTION.
RX   PubMed=32039410; DOI=10.1039/c9cc09590j;
RA   Hantke V., Skellam E.J., Cox R.J.;
RT   "Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization
RT   during the biosynthesis of pyrichalasin H.";
RL   Chem. Commun. (Camb.) 56:2925-2928(2020).
CC   -!- FUNCTION: Transcription factor that positively regulates the expression
CC       of the gene cluster that mediates the biosynthesis of oxaleimides,
CC       cytotoxic compounds containing an unusual disubstituted succinimide
CC       moiety. {ECO:0000269|PubMed:28365998}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; KY764291; ARF05976.1; -; Genomic_DNA.
DR   SMR; A0A1W5T1T3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..574
FT                   /note="C6 finger transcription factor poxB"
FT                   /id="PRO_0000453769"
FT   DNA_BIND        19..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          111..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  62081 MW;  26ADAF6C75999140 CRC64;
     MSEAEPSVVV AEQCRRSACD RCRGQKLRCE RPVSNSSTTP CRRCLKAHVR CVTTAQPHRT
     KPLSSLQYLH HTESNYDPHS ATVAGQLPVA AVAGLGDLDP SLLHMTGVQN PRRLSHSSSM
     ANPVDSRPPG RTRRLSNPDH FLPHPPLHPN GVLDTDGTPL LDSIDHLPDM TASRGFGFSA
     ALTPHSPSGS SDFFDYFRPM AEDNNRSPWM DAFTNLPPDH REGTPAGSNY RGSLTGENQF
     RSSLQSSRGL NGFETPQRES RHREMDIVSI KNECIARMGK LNRGLLQDVG LVNSGKVAGT
     LLFSQASRST YLEVEKGRKG GQNYVIGKML HSSKELLDIL KQLERCKSTL FPPGHTERTT
     STADEVTTAM TETTTLNQTG SHAPSSPLGG NPLPPLSGPL SASASHSSSC ASSSSASAST
     SGASLLSSST SAPSTSPAIS LQLDTTLTLL FLTGYTSVIQ LYEGVFSFIR DSVAANPSGS
     NFLPTLPKLQ VDGFEVGSST RDLQICILLQ VSTHILNQIE ERLHAIRDRA EGHVPAALLD
     TILDRSDPSQ RGAKGRELCR IVRDIKEHLK HYAE