ID   POXIN_BOMMO             Reviewed;         255 AA.
AC   H9JU86;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Poxin {ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000303|PubMed:30728498};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000269|PubMed:30728498};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p50T {ECO:0000312|EnsemblMetazoa:BGIBMGA013098-TA};
RX   PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG   International Silkworm Genome Consortium;
RT   "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL   Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=30728498; DOI=10.1038/s41586-019-0928-6;
RA   Eaglesham J.B., Pan Y., Kupper T.S., Kranzusch P.J.;
RT   "Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-
RT   STING signalling.";
RL   Nature 566:259-263(2019).
CC   -!- FUNCTION: Nuclease that cleaves 2',3'-cGAMP. {ECO:0000255|HAMAP-
CC       Rule:MF_04143, ECO:0000269|PubMed:30728498}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+);
CC         Xref=Rhea:RHEA:59472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:143093, ChEBI:CHEBI:143098; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_04143, ECO:0000269|PubMed:30728498};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59473;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_04143,
CC         ECO:0000305|PubMed:30728498};
CC   -!- SIMILARITY: Belongs to the poxin family. Highly divergent.
CC       {ECO:0000255|HAMAP-Rule:MF_04143}.
CC   -!- CAUTION: The active site cannot be determined by similarity to the
CC       viral poxins. {ECO:0000255|HAMAP-Rule:MF_04143,
CC       ECO:0000269|PubMed:30728498}.
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DR   EMBL; BABH01004247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004929020.1; XM_004928963.2.
DR   AlphaFoldDB; H9JU86; -.
DR   SMR; H9JU86; -.
DR   EnsemblMetazoa; BGIBMGA013098-RA; BGIBMGA013098-TA; BGIBMGA013098.
DR   eggNOG; ENOG502TBFA; Eukaryota.
DR   HOGENOM; CLU_1070683_0_0_1; -.
DR   InParanoid; H9JU86; -.
DR   OMA; AQWRCAP; -.
DR   OrthoDB; 1332104at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0061507; F:2',3'-cyclic GMP-AMP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04143; Poxins; 1.
DR   InterPro; IPR006853; Poxin_vir.
PE   1: Evidence at protein level;
KW   Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..255
FT                   /note="Poxin"
FT                   /id="PRO_0000446971"
SQ   SEQUENCE   255 AA;  28157 MW;  D0626337A06E623F CRC64;
     MTGIVELDLR MLKKKTAMSK RTVLNENYKG IVESMSIPAE IHERNGKKYA SVGSILPIHC
     CPPEELERRA ESTHHYCGVF TDELLAPLEE LAYVRLDENT AEKVFINRAK RILIVSSDGH
     LAQWRCAPTF ESANRYIAGT PIVDQRGGVI SVVVAKKNNH YAVSSFEGEG GYFESTQNWK
     VVEPAAGGYA YGELTFPSRT ALREHVAGLR GGAGAWGDAV PVLRGGTSPR LALVLDGRQL
     AHYYLHNVIV DVEYL