POXM_DROME
ID POXM_DROME Reviewed; 370 AA.
AC P23757; A4K7U1; Q1RL17; Q9VHS5;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Paired box pox-meso protein;
DE AltName: Full=Paired box mesodermal protein;
GN Name=Poxm; Synonyms=POX-M; ORFNames=CG9610;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17942482; DOI=10.1242/dev.008821;
RA Duan H., Zhang C., Chen J., Sink H., Frei E., Noll M.;
RT "A key role of Pox meso in somatic myogenesis of Drosophila.";
RL Development 134:3985-3997(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.W.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=2573516; DOI=10.1002/j.1460-2075.1989.tb08509.x;
RA Bopp D., Jamet E., Baumgartner S., Burri M., Noll M.;
RT "Isolation of two tissue-specific Drosophila paired box genes, Pox meso and
RT Pox neuro.";
RL EMBO J. 8:3447-3457(1989).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00381,
CC ECO:0000269|PubMed:2573516}.
CC -!- TISSUE SPECIFICITY: Expressed in somatic mesoderm.
CC {ECO:0000269|PubMed:2573516}.
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DR EMBL; DQ459353; ABE69188.1; -; mRNA.
DR EMBL; DQ459354; ABE69189.1; -; mRNA.
DR EMBL; AE014297; ABI31147.1; -; Genomic_DNA.
DR EMBL; BT025043; ABE73214.1; -; mRNA.
DR EMBL; X16992; CAA34860.1; -; Genomic_DNA.
DR PIR; S06950; S06950.
DR RefSeq; NP_001036687.1; NM_001043222.3.
DR AlphaFoldDB; P23757; -.
DR SMR; P23757; -.
DR BioGRID; 66171; 55.
DR DIP; DIP-17081N; -.
DR IntAct; P23757; 42.
DR STRING; 7227.FBpp0110325; -.
DR PaxDb; P23757; -.
DR DNASU; 40990; -.
DR EnsemblMetazoa; FBtr0111026; FBpp0110325; FBgn0003129.
DR GeneID; 40990; -.
DR KEGG; dme:Dmel_CG9610; -.
DR CTD; 40990; -.
DR FlyBase; FBgn0003129; Poxm.
DR VEuPathDB; VectorBase:FBgn0003129; -.
DR eggNOG; KOG3517; Eukaryota.
DR GeneTree; ENSGT00940000159137; -.
DR HOGENOM; CLU_019281_6_1_1; -.
DR InParanoid; P23757; -.
DR OMA; VGMGNTV; -.
DR OrthoDB; 1339212at2759; -.
DR SignaLink; P23757; -.
DR BioGRID-ORCS; 40990; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Poxm; fly.
DR GenomeRNAi; 40990; -.
DR PRO; PR:P23757; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0003129; Expressed in esophagus primordium (Drosophila) and 14 other tissues.
DR Genevisible; P23757; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Paired box;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..370
FT /note="Paired box pox-meso protein"
FT /id="PRO_0000050170"
FT DNA_BIND 9..135
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 12..68
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 87..135
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 139..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 38388 MW; 73932D0001019C32 CRC64;
MDPESQCPQY GEVNQLGGVF VNGRPLPNAT RMRIVELARL GIRPCDISRQ LRVSHGCVSK
ILARYHETGS ILPGAIGGSK PRVTTPKVVN YIRELKQRDP GIFAWEIRDR LLSEGICDKT
NVPSVSSISR ILRNKLGSLG HQHTPGTVMG SGSSSGGGSV SSNGGQNNGT SASNNINLSN
LGNPGGGPHH PHHHHHHQSA AAAASAHHVH AHAHAHAHLY NSIYQPYSAA AAYSMKTPCG
SPSPPQGAGG QGSVPHPHQL RSVAAAAAAA HWPSSHSVSD ILAHHQAVAL RASCQVGVGV
GGMGGMGSTV SPLPMTPSPV AGTAGGQPLL DCEGGAGQQS PYNYYMYFQN GGMHHHHHHG
GMMAAGATGL
