POXN_DROME
ID POXN_DROME Reviewed; 425 AA.
AC P23758; Q9V7F3;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2003, sequence version 3.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Paired box pox-neuro protein;
DE AltName: Full=Paired box neuronal protein;
GN Name=Poxn; Synonyms=pox-n; ORFNames=CG8246;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1348214; DOI=10.1016/0092-8674(92)90127-x;
RA Dambly-Chaudiere C., Jamet E., Burri M., Bopp D., Basler K., Hafen E.,
RA Dumont N., Spielmann P., Ghysen A., Noll M.;
RT "The paired box gene pox neuro: a determinant of poly-innervated sense
RT organs in Drosophila.";
RL Cell 69:159-172(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 1-35.
RX PubMed=2573516; DOI=10.1002/j.1460-2075.1989.tb08509.x;
RA Bopp D., Jamet E., Baumgartner S., Burri M., Noll M.;
RT "Isolation of two tissue-specific Drosophila paired box genes, Pox meso and
RT Pox neuro.";
RL EMBO J. 8:3447-3457(1989).
RN [5]
RP FUNCTION.
RX PubMed=8292359; DOI=10.1016/0896-6273(94)90149-x;
RA Nottebohm E., Usui A., Therianos S., Kimura K., Dambly-Chaudiere C.,
RA Ghysen A.;
RT "The gene poxn controls different steps of the formation of chemosensory
RT organs in Drosophila.";
RL Neuron 12:25-34(1994).
RN [6]
RP FUNCTION.
RX PubMed=9183748;
RX DOI=10.1002/(sici)1097-4695(19970620)32:7<707::aid-neu6>3.0.co;2-8;
RA Awasaki T., Kimura K.;
RT "pox-neuro is required for development of chemosensory bristles in
RT Drosophila.";
RL J. Neurobiol. 32:707-721(1997).
CC -!- FUNCTION: Transcriptional regulator that specifies poly-innervated
CC organs (chemosensory bristle). Also controls the number of neurons.
CC {ECO:0000269|PubMed:8292359, ECO:0000269|PubMed:9183748}.
CC -!- INTERACTION:
CC P23758; A0A0B4KEQ7: Dmel\CG10209; NbExp=3; IntAct=EBI-105329, EBI-15107367;
CC P23758; P02835: ftz; NbExp=3; IntAct=EBI-105329, EBI-125786;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Central and peripheral nervous systems.
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DR EMBL; M86927; AAA28832.1; -; mRNA.
DR EMBL; AE013599; AAF58104.1; -; Genomic_DNA.
DR EMBL; X58917; CAA41721.1; -; Genomic_DNA.
DR PIR; A38153; A38153.
DR RefSeq; NP_001261016.1; NM_001274087.1.
DR RefSeq; NP_476686.1; NM_057338.3.
DR AlphaFoldDB; P23758; -.
DR SMR; P23758; -.
DR BioGRID; 62469; 19.
DR DIP; DIP-23815N; -.
DR IntAct; P23758; 31.
DR STRING; 7227.FBpp0302942; -.
DR PaxDb; P23758; -.
DR ABCD; P23758; 3 sequenced antibodies.
DR DNASU; 36741; -.
DR EnsemblMetazoa; FBtr0087311; FBpp0086446; FBgn0003130.
DR EnsemblMetazoa; FBtr0329908; FBpp0302942; FBgn0003130.
DR GeneID; 36741; -.
DR KEGG; dme:Dmel_CG8246; -.
DR CTD; 36741; -.
DR FlyBase; FBgn0003130; Poxn.
DR VEuPathDB; VectorBase:FBgn0003130; -.
DR eggNOG; KOG3862; Eukaryota.
DR HOGENOM; CLU_019664_0_0_1; -.
DR InParanoid; P23758; -.
DR OMA; CGVRPCD; -.
DR OrthoDB; 744048at2759; -.
DR PhylomeDB; P23758; -.
DR SignaLink; P23758; -.
DR BioGRID-ORCS; 36741; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36741; -.
DR PRO; PR:P23758; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0003130; Expressed in sensory nervous system primordium (Drosophila) and 16 other tissues.
DR ExpressionAtlas; P23758; baseline and differential.
DR Genevisible; P23758; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008343; P:adult feeding behavior; IMP:FlyBase.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0048800; P:antennal morphogenesis; IMP:FlyBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009415; P:response to water; IDA:FlyBase.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Paired box; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..425
FT /note="Paired box pox-neuro protein"
FT /id="PRO_0000050171"
FT DNA_BIND 5..132
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 8..64
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 84..132
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 159..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..425
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 343
FT /note="P -> T (in Ref. 1; AAA28832)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="S -> R (in Ref. 1; AAA28832)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="A -> G (in Ref. 1; AAA28832)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 44329 MW; 59B01A4F97C1B126 CRC64;
MPHTGQAGVN QLGGVFVNGR PLPDCVRRRI VDLALCGVRP CDISRQLLVS HGCVSKILTR
FYETGSIRPG SIGGSKTKQV ATPTVVKKII RLKEENSGMF AWEIREQLQQ QRVCDPSSVP
SISSINRILR NSGLWTDEMT SSQQNAAAAA AAAAAAAHQA GSGPSNGYGG QAPPPPVTVA
PPTPAATPSI ARYAKPPALM MNSAGEMPIK PAPKMPPSMG HGHSHGLNPN VSGLDLSYSA
LHKHWLWNPS LLYYTQAHIQ AQAAASGGQF LPYAGGYLPH AMAAAAASST SALGGFTKSE
SSIDLSTPGA AGDALSDCDS GKSSPAALSL TASGGGNGAG SAPEASPGST LSHSRKRNPY
SIEELLKKPE KRLRLDSNRL ECLESSSCES SQDSPVAPPL ETPEDEDPAE AEEEQEEEDS
VEVVN
