POZP3_HUMAN
ID POZP3_HUMAN Reviewed; 187 AA.
AC Q6PJE2; F6STJ3; Q12903; Q9BWB4;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 4.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=POM121 and ZP3 fusion protein;
DE Short=POM-ZP3;
GN Name=POMZP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Ovary;
RX PubMed=7789967; DOI=10.1016/0888-7543(95)80033-i;
RA Kipersztok S., Osawa G.A., Liang L.-F., Modi W.S., Dean J.;
RT "POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121
RT homologue.";
RL Genomics 25:354-359(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PJE2-4; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PJE2-5; Sequence=VSP_046257;
CC -!- TISSUE SPECIFICITY: Expressed in spleen, thymus, pancreas, testis,
CC ovary, small intestine, colon and lymphocytes.
CC {ECO:0000269|PubMed:7789967}.
CC -!- CAUTION: The POM-ZP3 transcript appears to have arisen from a partial
CC duplication and fusion of a 5' portion of a POM121 homolog and exons 5-
CC 8 of ZP3. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA85788.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U10099; AAA85788.1; ALT_FRAME; mRNA.
DR EMBL; AC004980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43606.1; -. [Q6PJE2-4]
DR CCDS; CCDS5590.1; -. [Q6PJE2-5]
DR PIR; A56844; A56844.
DR PIR; B44365; B44365.
DR RefSeq; NP_036362.3; NM_012230.3. [Q6PJE2-4]
DR RefSeq; NP_694537.1; NM_152992.2. [Q6PJE2-5]
DR AlphaFoldDB; Q6PJE2; -.
DR SMR; Q6PJE2; -.
DR BioGRID; 116592; 9.
DR IntAct; Q6PJE2; 2.
DR MINT; Q6PJE2; -.
DR STRING; 9606.ENSP00000309233; -.
DR iPTMnet; Q6PJE2; -.
DR PhosphoSitePlus; Q6PJE2; -.
DR BioMuta; POMZP3; -.
DR EPD; Q6PJE2; -.
DR jPOST; Q6PJE2; -.
DR MassIVE; Q6PJE2; -.
DR MaxQB; Q6PJE2; -.
DR PaxDb; Q6PJE2; -.
DR PeptideAtlas; Q6PJE2; -.
DR PRIDE; Q6PJE2; -.
DR ProteomicsDB; 27940; -.
DR ProteomicsDB; 67198; -. [Q6PJE2-4]
DR Antibodypedia; 29359; 106 antibodies from 17 providers.
DR DNASU; 22932; -.
DR Ensembl; ENST00000275569.8; ENSP00000275569.4; ENSG00000146707.15. [Q6PJE2-5]
DR Ensembl; ENST00000310842.9; ENSP00000309233.4; ENSG00000146707.15. [Q6PJE2-4]
DR Ensembl; ENST00000615241.2; ENSP00000484663.1; ENSG00000276464.4. [Q6PJE2-5]
DR Ensembl; ENST00000619075.4; ENSP00000477906.1; ENSG00000276464.4. [Q6PJE2-4]
DR GeneID; 22932; -.
DR KEGG; hsa:22932; -.
DR MANE-Select; ENST00000310842.9; ENSP00000309233.4; NM_012230.5; NP_036362.3.
DR UCSC; uc003uft.4; human. [Q6PJE2-4]
DR CTD; 22932; -.
DR DisGeNET; 22932; -.
DR GeneCards; POMZP3; -.
DR HGNC; HGNC:9203; POMZP3.
DR HPA; ENSG00000146707; Low tissue specificity.
DR MIM; 600587; gene.
DR neXtProt; NX_Q6PJE2; -.
DR OpenTargets; ENSG00000146707; -.
DR VEuPathDB; HostDB:ENSG00000146707; -.
DR eggNOG; ENOG502QSZF; Eukaryota.
DR GeneTree; ENSGT01030000234567; -.
DR HOGENOM; CLU_2108194_0_0_1; -.
DR InParanoid; Q6PJE2; -.
DR OrthoDB; 495227at2759; -.
DR PhylomeDB; Q6PJE2; -.
DR PathwayCommons; Q6PJE2; -.
DR SignaLink; Q6PJE2; -.
DR BioGRID-ORCS; 22932; 28 hits in 1005 CRISPR screens.
DR ChiTaRS; POMZP3; human.
DR GenomeRNAi; 22932; -.
DR Pharos; Q6PJE2; Tdark.
DR PRO; PR:Q6PJE2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6PJE2; protein.
DR Bgee; ENSG00000146707; Expressed in left testis and 96 other tissues.
DR ExpressionAtlas; Q6PJE2; baseline and differential.
DR Genevisible; Q6PJE2; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0032190; F:acrosin binding; IBA:GO_Central.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
DR GO; GO:0035803; P:egg coat formation; IBA:GO_Central.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; IBA:GO_Central.
DR Gene3D; 2.60.40.4100; -; 1.
DR InterPro; IPR026054; Nucleoporin.
DR InterPro; IPR026090; POM121.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR23193; PTHR23193; 1.
DR PANTHER; PTHR23193:SF43; PTHR23193:SF43; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..187
FT /note="POM121 and ZP3 fusion protein"
FT /id="PRO_0000204909"
FT REGION 166..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 116..187
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046257"
FT VARIANT 176
FT /note="R -> H (in dbSNP:rs1065538)"
FT /id="VAR_056721"
SQ SEQUENCE 187 AA; 20620 MW; EF36674F9192196F CRC64;
MVCSPVTLRI APPDRRFSRS AIPEQIISST LSSPSSNAPD PCAKETVLSA LKEKKKKRTV
EEEDQIFLDG QENKRSCLVD GLTDASSAFK VPRPGPDTLQ FTVDVFHFAN DSRNMIYITC
HLKVTLAEQD PDELNKACSF SKPSNSWFPV EGLADICQCC NKGDCGTPSH SRRQPRVVSQ
WSTSASL
