PP13G_MOUSE
ID PP13G_MOUSE Reviewed; 347 AA.
AC Q9CW07;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 3G;
GN Name=Ppp1r3g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-347.
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=21471512; DOI=10.2337/db10-1663;
RA Luo X., Zhang Y., Ruan X., Jiang X., Zhu L., Wang X., Ding Q., Liu W.,
RA Pan Y., Wang Z., Chen Y.;
RT "Fasting-induced protein phosphatase 1 regulatory subunit contributes to
RT postprandial blood glucose homeostasis via regulation of hepatic
RT glycogenesis.";
RL Diabetes 60:1435-1445(2011).
CC -!- FUNCTION: Glycogen-targeting subunit for protein phosphatase 1 (PP1).
CC Involved in the regulation of hepatic glycogenesis in a manner coupled
CC to the fasting-feeding cycle and distinct from other glycogen-targeting
CC subunits. {ECO:0000269|PubMed:21471512}.
CC -!- INDUCTION: Up-regulated during fasting and down-regulated after
CC feeding. {ECO:0000269|PubMed:21471512}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24130.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC134860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK005570; BAB24130.1; ALT_FRAME; mRNA.
DR CCDS; CCDS49237.1; -.
DR RefSeq; NP_083904.1; NM_029628.1.
DR RefSeq; XP_006516866.1; XM_006516803.3.
DR RefSeq; XP_006516867.1; XM_006516804.2.
DR AlphaFoldDB; Q9CW07; -.
DR SMR; Q9CW07; -.
DR BioGRID; 218151; 1.
DR STRING; 10090.ENSMUSP00000122712; -.
DR iPTMnet; Q9CW07; -.
DR PhosphoSitePlus; Q9CW07; -.
DR MaxQB; Q9CW07; -.
DR PaxDb; Q9CW07; -.
DR PRIDE; Q9CW07; -.
DR ProteomicsDB; 289781; -.
DR Antibodypedia; 58036; 58 antibodies from 12 providers.
DR Ensembl; ENSMUST00000132661; ENSMUSP00000122712; ENSMUSG00000050423.
DR Ensembl; ENSMUST00000225537; ENSMUSP00000153702; ENSMUSG00000050423.
DR GeneID; 76487; -.
DR KEGG; mmu:76487; -.
DR UCSC; uc007qci.2; mouse.
DR CTD; 648791; -.
DR MGI; MGI:1923737; Ppp1r3g.
DR VEuPathDB; HostDB:ENSMUSG00000050423; -.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00940000163747; -.
DR HOGENOM; CLU_040215_1_0_1; -.
DR InParanoid; Q9CW07; -.
DR OMA; GAECFHF; -.
DR OrthoDB; 1232750at2759; -.
DR PhylomeDB; Q9CW07; -.
DR TreeFam; TF105537; -.
DR BioGRID-ORCS; 76487; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Ppp1r3g; mouse.
DR PRO; PR:Q9CW07; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CW07; protein.
DR Bgee; ENSMUSG00000050423; Expressed in lumbar subsegment of spinal cord and 38 other tissues.
DR Genevisible; Q9CW07; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:2001069; F:glycogen binding; IDA:MGI.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; IPI:MGI.
DR GO; GO:0042593; P:glucose homeostasis; IDA:MGI.
DR GO; GO:0005978; P:glycogen biosynthetic process; IDA:MGI.
DR GO; GO:2000467; P:positive regulation of glycogen (starch) synthase activity; IDA:MGI.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IDA:MGI.
DR GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.40.2440; -; 1.
DR InterPro; IPR005036; CBM21_dom.
DR InterPro; IPR038175; CBM21_dom_sf.
DR Pfam; PF03370; CBM_21; 1.
DR PROSITE; PS51159; CBM21; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..347
FT /note="Protein phosphatase 1 regulatory subunit 3G"
FT /id="PRO_0000394966"
FT DOMAIN 200..339
FT /note="CBM21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 347 AA; 37823 MW; 5485AD47C87CA657 CRC64;
MDPSGEQLHR SEASSSTSSG DPQSAEELSV PEVLCVESGT SETPIPDAQL QDRPLSPQKG
AALPEQEELQ EYRRSRARSF SLPADPILQA AKLLQQRQQA GQPSSEGGAP AGDCCSKCKK
RVQFADSLGL SLASVKHFSE AEEPQVPPAV LSRLHSFPLR AEDLQQLGGL LAVATMPDPL
LVPCARLRPH FQLPELRAAE ERLRRQRVCL ERVQCSQPPR AEVTGSGRVI SCPGPRAVAV
RYTFTEWRTF LDVPAELDPE SVEPLPPLQS GDSGSKAEDS EEGPGTERFH FSLCLPPGLQ
PKEGEDAGAW GVAIHFAVCY RCEQGEYWDN NEGANYTLRY VCSTDPL
