ID   PP14D_RAT               Reviewed;         146 AA.
AC   Q8K3F4;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 14D;
DE   AltName: Full=Gastrointestinal and brain-specific PP1-inhibitory protein 1;
DE            Short=GBPI-1;
GN   Name=Ppp1r14d; Synonyms=Gbpi;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12974676; DOI=10.1042/bj20030128;
RA   Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J.,
RA   Uhl G.R.;
RT   "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein,
RT   is activated by PKC and inactivated by PKA.";
RL   Biochem. J. 377:171-181(2004).
CC   -!- FUNCTION: Inhibitor of PPP1CA. Has inhibitory activity only when
CC       phosphorylated, creating a molecular switch for regulating the
CC       phosphorylation status of PPP1CA substrates and smooth muscle
CC       contraction (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated on several residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PP1 inhibitor family. {ECO:0000305}.
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DR   EMBL; AY122322; AAM89291.1; -; mRNA.
DR   RefSeq; NP_742008.1; NM_172011.1.
DR   AlphaFoldDB; Q8K3F4; -.
DR   STRING; 10116.ENSRNOP00000017070; -.
DR   PhosphoSitePlus; Q8K3F4; -.
DR   PaxDb; Q8K3F4; -.
DR   GeneID; 259226; -.
DR   KEGG; rno:259226; -.
DR   UCSC; RGD:628891; rat.
DR   CTD; 54866; -.
DR   RGD; 628891; Ppp1r14d.
DR   VEuPathDB; HostDB:ENSRNOG00000012648; -.
DR   eggNOG; ENOG502RZZY; Eukaryota.
DR   HOGENOM; CLU_114155_0_0_1; -.
DR   InParanoid; Q8K3F4; -.
DR   OMA; PDEGQRT; -.
DR   OrthoDB; 1555484at2759; -.
DR   PhylomeDB; Q8K3F4; -.
DR   TreeFam; TF105546; -.
DR   PRO; PR:Q8K3F4; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000012648; Expressed in duodenum and 14 other tissues.
DR   ExpressionAtlas; Q8K3F4; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:1905183; P:negative regulation of protein serine/threonine phosphatase activity; ISS:UniProtKB.
DR   GO; GO:1905184; P:positive regulation of protein serine/threonine phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0042325; P:regulation of phosphorylation; IEA:InterPro.
DR   Gene3D; 1.10.150.220; -; 1.
DR   InterPro; IPR008025; CPI-17.
DR   InterPro; IPR036658; CPI-17_sf.
DR   PANTHER; PTHR16188; PTHR16188; 1.
DR   Pfam; PF05361; PP1_inhibitor; 1.
DR   SUPFAM; SSF81790; SSF81790; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Protein phosphatase inhibitor;
KW   Reference proteome.
FT   CHAIN           1..146
FT                   /note="Protein phosphatase 1 regulatory subunit 14D"
FT                   /id="PRO_0000071499"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          21..25
FT                   /note="Interaction with protein phosphatase 1"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   146 AA;  16867 MW;  E614CFC25DF508DA CRC64;
     MLSSSAASCT SPNPDTDNPD KKVRWSSEKR RRASSTDSES KTHLDISKLP RSRRPSRLTV
     KYDRGHLQRW LEMEQWVDAQ VQELFQGQAD TSEPEIDLEA LMELSTDEQR TQLEAILQDC
     PGNREPFISE LLSQLKRLRR LSRPSK