PP1R7_ARATH
ID PP1R7_ARATH Reviewed; 328 AA.
AC Q84WJ9; Q8LG14;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Protein phosphatase 1 regulatory inhibitor subunit PPP1R7 homolog {ECO:0000305};
GN OrderedLocusNames=At5g19680 {ECO:0000312|Araport:AT5G19680};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH HUMAN PROTEIN
RP PHOSPHATASE PPP1CC.
RX PubMed=21222654; DOI=10.1042/bj20101035;
RA Templeton G.W., Nimick M., Morrice N., Campbell D., Goudreault M.,
RA Gingras A.C., Takemiya A., Shimazaki K., Moorhead G.B.;
RT "Identification and characterization of AtI-2, an Arabidopsis homologue of
RT an ancient protein phosphatase 1 (PP1) regulatory subunit.";
RL Biochem. J. 435:73-83(2011).
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1 (PP1). Binds to and
CC inhibits PP1 activity. {ECO:0000250|UniProtKB:Q9LTK0}.
CC -!- SUBUNIT: Interacts with human protein phosphatase PPP1C.
CC {ECO:0000269|PubMed:21222654}.
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DR EMBL; AF296838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92737.1; -; Genomic_DNA.
DR EMBL; BT003139; AAO24571.1; -; mRNA.
DR EMBL; AK228123; BAF00080.1; -; mRNA.
DR EMBL; AY084519; AAM61087.1; -; mRNA.
DR RefSeq; NP_197469.1; NM_121973.5.
DR AlphaFoldDB; Q84WJ9; -.
DR SMR; Q84WJ9; -.
DR IntAct; Q84WJ9; 2.
DR STRING; 3702.AT5G19680.1; -.
DR PaxDb; Q84WJ9; -.
DR PRIDE; Q84WJ9; -.
DR ProteomicsDB; 249083; -.
DR EnsemblPlants; AT5G19680.1; AT5G19680.1; AT5G19680.
DR GeneID; 832088; -.
DR Gramene; AT5G19680.1; AT5G19680.1; AT5G19680.
DR KEGG; ath:AT5G19680; -.
DR Araport; AT5G19680; -.
DR TAIR; locus:2183144; AT5G19680.
DR eggNOG; KOG0531; Eukaryota.
DR HOGENOM; CLU_044236_1_1_1; -.
DR InParanoid; Q84WJ9; -.
DR OMA; VIENIAH; -.
DR OrthoDB; 968788at2759; -.
DR PhylomeDB; Q84WJ9; -.
DR PRO; PR:Q84WJ9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q84WJ9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IGI:TAIR.
DR GO; GO:0034504; P:protein localization to nucleus; IGI:TAIR.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13516; LRR_6; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 11.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Protein phosphatase inhibitor; Reference proteome;
KW Repeat.
FT CHAIN 1..328
FT /note="Protein phosphatase 1 regulatory inhibitor subunit
FT PPP1R7 homolog"
FT /id="PRO_0000442226"
FT REPEAT 13..36
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 37..59
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 61..82
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 86..110
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 111..130
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 131..153
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 154..177
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 179..196
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 197..221
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 223..240
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 241..264
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 266..287
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 289..312
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT CONFLICT 4..7
FT /note="EKED -> DKEE (in Ref. 5; AAM61087)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="L -> I (in Ref. 5; AAM61087)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 36985 MW; CAE82B82473D7AC4 CRC64;
MNSEKEDEPL EEIGDSNNVL DLTSYQLHSL DTVELPPNLI ELDLTANRLS GLDSRIAQLS
TLKKLSLRQN LIDDSAVEPL SHWDALSDLE ELVLRDNKLA KVPDVSIFTK LLVYDISFNE
ITSLEGISKA SSTLKELYVS KNEVNKIMEI EHLHNLQILE LGSNRLRVME NLENFTKLEE
LWLGRNRIKV VNLCGLKCIK KISLQSNRLT SMKGFEECVA LEELYLSHNG ISKMEGLSAL
VNLRVLDVSN NKLTSVDDIQ NLTKLEDLWL NDNQIESLEA ITEAVTGSKE KLTTIYLENN
PCAKSSDYVA AVRQIFPNVE QIDSNLFA
