ID   PP1R7_DICDI             Reviewed;         336 AA.
AC   Q54Q39; O15732;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit pprA;
GN   Name=pprA; ORFNames=DDB_G0284039;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 183-336.
RC   STRAIN=AX4;
RA   Loomis W.F., Iranfar N.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of protein phosphatase 1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDS22 family. {ECO:0000305}.
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DR   EMBL; AAFI02000063; EAL65360.1; -; Genomic_DNA.
DR   EMBL; AF018639; AAB82534.1; -; Genomic_DNA.
DR   RefSeq; XP_638758.1; XM_633666.1.
DR   AlphaFoldDB; Q54Q39; -.
DR   SMR; Q54Q39; -.
DR   STRING; 44689.DDB0191475; -.
DR   PaxDb; Q54Q39; -.
DR   EnsemblProtists; EAL65360; EAL65360; DDB_G0284039.
DR   GeneID; 8624429; -.
DR   KEGG; ddi:DDB_G0284039; -.
DR   dictyBase; DDB_G0284039; pprA.
DR   eggNOG; KOG0531; Eukaryota.
DR   HOGENOM; CLU_044236_0_0_1; -.
DR   InParanoid; Q54Q39; -.
DR   OMA; YDNLIAH; -.
DR   PhylomeDB; Q54Q39; -.
DR   PRO; PR:Q54Q39; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00446; LRRcap; 1.
DR   PROSITE; PS51450; LRR; 10.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..336
FT                   /note="Protein phosphatase 1 regulatory subunit pprA"
FT                   /id="PRO_0000328155"
FT   REPEAT          26..47
FT                   /note="LRR 1"
FT   REPEAT          49..70
FT                   /note="LRR 2"
FT   REPEAT          71..92
FT                   /note="LRR 3"
FT   REPEAT          93..114
FT                   /note="LRR 4"
FT   REPEAT          115..136
FT                   /note="LRR 5"
FT   REPEAT          139..160
FT                   /note="LRR 6"
FT   REPEAT          161..182
FT                   /note="LRR 7"
FT   REPEAT          183..204
FT                   /note="LRR 8"
FT   REPEAT          205..225
FT                   /note="LRR 9"
FT   REPEAT          229..250
FT                   /note="LRR 10"
FT   REPEAT          251..272
FT                   /note="LRR 11"
FT   REPEAT          273..294
FT                   /note="LRR 12"
FT   DOMAIN          306..336
FT                   /note="LRRCT"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  38952 MW;  E0AB4F1A4D6058BD CRC64;
     MSEQNTIINS EEIKENEKIE SETEEPITYL DLTGQPHTSI GDSYNIPETL LDLDLTNCKI
     TKIENINHLK NLKKLCFRQN LIEKIENIDQ LKELESLDLY DNKLQVIENI KDFQSLTYLD
     LSFNEIRIVE NLSIKDIPKI KELYLANNKI TKIENLQELV PIKNLELGSN RLREIENLEN
     LVNIETLWLG RNKITEIKGI NHLSHLRILS LQSNRLTEIG VKGLVGLNCL EELYLSHNGI
     TDIDGLQSLK QLRTLDISAN KIKTLVGLNE LPDLDEIWCN DNLVDSMDNI EQQVTKSIKC
     LYFERNPVAT HVQYRRMFIN MFPQLKQLDA TMVKRN