PP1R7_RAT
ID PP1R7_RAT Reviewed; 360 AA.
AC Q5HZV9;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 7;
DE AltName: Full=Protein phosphatase 1 regulatory subunit 22;
GN Name=Ppp1r7; Synonyms=Sds22;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 276-285, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (JUL-2007) to UniProtKB.
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=7498485; DOI=10.1016/0014-5793(95)01180-m;
RA Renouf S., Beullens M., Wera S., Van Eynde A., Sikela J., Stalmans W.,
RA Bollen M.;
RT "Molecular cloning of a human polypeptide related to yeast sds22, a
RT regulator of protein phosphatase-1.";
RL FEBS Lett. 375:75-78(1995).
RN [4]
RP ALTERNATIVE SPLICING, AND SUBCELLULAR LOCATION.
RC TISSUE=Liver;
RX PubMed=12555814; DOI=10.1139/o02-155;
RA Tran H.T., Bridges D., Ulke A., Moorhead G.B.;
RT "Detection of multiple splice variants of the nuclear protein phosphatase 1
RT regulator sds22 in rat liver nuclei.";
RL Biochem. Cell Biol. 80:811-815(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-24; SER-27; SER-44;
RP SER-47 AND SER-322, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Regulatory subunit of protein phosphatase 1. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12555814,
CC ECO:0000269|PubMed:7498485}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.;
CC Name=1;
CC IsoId=Q5HZV9-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the SDS22 family. {ECO:0000305}.
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DR EMBL; BC088868; AAH88868.1; -; mRNA.
DR RefSeq; NP_001009825.1; NM_001009825.1. [Q5HZV9-1]
DR AlphaFoldDB; Q5HZV9; -.
DR SMR; Q5HZV9; -.
DR BioGRID; 257021; 1.
DR IntAct; Q5HZV9; 1.
DR STRING; 10116.ENSRNOP00000022854; -.
DR iPTMnet; Q5HZV9; -.
DR PhosphoSitePlus; Q5HZV9; -.
DR jPOST; Q5HZV9; -.
DR PaxDb; Q5HZV9; -.
DR PRIDE; Q5HZV9; -.
DR Ensembl; ENSRNOT00000095497; ENSRNOP00000081944; ENSRNOG00000016974. [Q5HZV9-1]
DR GeneID; 301618; -.
DR KEGG; rno:301618; -.
DR UCSC; RGD:1308169; rat. [Q5HZV9-1]
DR CTD; 5510; -.
DR RGD; 1308169; Ppp1r7.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000158551; -.
DR InParanoid; Q5HZV9; -.
DR OrthoDB; 968788at2759; -.
DR PhylomeDB; Q5HZV9; -.
DR TreeFam; TF105538; -.
DR PRO; PR:Q5HZV9; -.
DR Proteomes; UP000002494; Chromosome 9.
DR GO; GO:0005694; C:chromosome; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; ISO:RGD.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISO:RGD.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR Pfam; PF12799; LRR_4; 2.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00446; LRRcap; 1.
DR PROSITE; PS51450; LRR; 12.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q15435"
FT CHAIN 2..360
FT /note="Protein phosphatase 1 regulatory subunit 7"
FT /id="PRO_0000239616"
FT REPEAT 77..98
FT /note="LRR 1"
FT REPEAT 99..120
FT /note="LRR 2"
FT REPEAT 121..142
FT /note="LRR 3"
FT REPEAT 143..164
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 187..208
FT /note="LRR 6"
FT REPEAT 209..230
FT /note="LRR 7"
FT REPEAT 231..252
FT /note="LRR 8"
FT REPEAT 253..274
FT /note="LRR 9"
FT REPEAT 275..296
FT /note="LRR 10"
FT REPEAT 297..318
FT /note="LRR 11"
FT DOMAIN 331..360
FT /note="LRRCT"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q15435"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 44
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 360 AA; 41297 MW; 1CDA9FB2ACC02400 CRC64;
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGIV ADLSQQSLKD GVERGAEDPE
EEHELAVDME TISLDRDAED VDLNHYRIGK IEGFEVLKKV KSLCLRQNLI KCIENLDELQ
SLRELDLYDN QIKKIENLEA LTELEVLDIS FNLLRNIEGI DKLTQLKKLF LVNNKINKIE
NISTLQQLQM LELGSNRIRA IENIDTLTNL ESLFLGKNKI TKLQNLDALS NLTVLSMQSN
RLTKIEGLQN LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE
FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV RQIDATFVRF
