ID   PP1RA_XENLA             Reviewed;         819 AA.
AC   Q6GLQ4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Serine/threonine-protein phosphatase 1 regulatory subunit 10;
GN   Name=ppp1r10;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable inhibitor of phosphatase activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074405; AAH74405.1; -; mRNA.
DR   RefSeq; NP_001086267.1; NM_001092798.1.
DR   AlphaFoldDB; Q6GLQ4; -.
DR   SMR; Q6GLQ4; -.
DR   DNASU; 444696; -.
DR   GeneID; 444696; -.
DR   KEGG; xla:444696; -.
DR   CTD; 444696; -.
DR   Xenbase; XB-GENE-6254587; ppp1r10.S.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 444696; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Pfam; PF08711; Med26; 1.
DR   SMART; SM00509; TFS2N; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Protein phosphatase inhibitor; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..819
FT                   /note="Serine/threonine-protein phosphatase 1 regulatory
FT                   subunit 10"
FT                   /id="PRO_0000071516"
FT   DOMAIN          73..147
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   ZN_FING         785..813
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          151..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           412..415
FT                   /note="PP1-binding motif"
FT   COMPBIAS        151..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..371
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..391
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..582
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..623
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..690
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        730..746
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..783
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   819 AA;  89326 MW;  7181CDA100215A6A CRC64;
     MGSGPIDPLE LLKGLDNILG QGGEVKALEG MAKIFNLMKQ SQKMVNRCIY LNIVLQTHSP
     DILSKFIRVG GYKLLNNWLT YARTCNNSPL LHQILLTLQH LPLTVDHLKQ NNTAKLVKQL
     SKSSEDEELR KLAGILVNDW MAVIRSQTNI QPADKEKKKK KEDAKGSSPV LDKTSEAKSE
     DNGDKKEKPK IQRTTAPSHA KFRSTGLEVE ASSLVPVKKP TPVPVLSDKY LKPVPVKRQS
     SVPVPGDAAP AEKKYKPLNI VPNTTKEIKV KIIPPQPIES LGFLDALNSA PVPGIKIKKK
     KKAVSPTSNK ASPFDSKSPT EASSLTKPSS PEPEPPVEGM EVERPGTPVP AIELPEPMEI
     SAPPPPAPSE TKPSEADASQ LTKKGKKRKT VSWPEESRLR EYFYFELDET ERVNVNKIKD
     FGEAAKREML KDRQAFQNAR RHSHDTMEEV IPWVLPRLLN LPGALVQMGS NSTEKHAQAE
     REMGILQEIF LSKESVPDTP HEPDPESYEP SPPKLIPLDE DCSMDDGVYP ESMDQSTESQ
     SPDLNGAKLP PVLANLMGSM GSSKSPPNTL PGTMQEILTS IMGAQGNAKP EDLMKQPDFS
     EKIKHLLGSL QNQNQNQGPP GPAGQGSQGP VNIGFPPPSQ KNHQPPPPHH QPPPPHYPPP
     GPNGPFQGPH GPPGGPRMMG PPPPQRDGYW EPPPNENLRG GSHHGGERGG MRGGDRGPPP
     PPFHRNRGGR GGEPGYRGRG RGGERGHPGR NGPYGMGHGD HRGHEGHRGH GGHGDHRGHG
     HGGDMSTRPT CRHFMMKGNC RYENNCAFYH PGINGPPLP