PP207_ARATH
ID PP207_ARATH Reviewed; 903 AA.
AC Q9FWA6; Q9SRU8;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Pentatricopeptide repeat-containing protein At3g02330, mitochondrial;
DE AltName: Full=Mitochondrial editing factor 13 {ECO:0000303|PubMed:26048647};
DE Flags: Precursor;
GN Name=PCMP-E90; Synonyms=MEF13 {ECO:0000303|PubMed:26048647};
GN OrderedLocusNames=At3g02330; ORFNames=F11A12.2, F14P3.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15269332; DOI=10.1105/tpc.104.022236;
RA Lurin C., Andres C., Aubourg S., Bellaoui M., Bitton F., Bruyere C.,
RA Caboche M., Debast C., Gualberto J., Hoffmann B., Lecharny A., Le Ret M.,
RA Martin-Magniette M.-L., Mireau H., Peeters N., Renou J.-P., Szurek B.,
RA Taconnat L., Small I.;
RT "Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins
RT reveals their essential role in organelle biogenesis.";
RL Plant Cell 16:2089-2103(2004).
RN [4]
RP FUNCTION, INTERACTION WITH MORF1/RIP8, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=26048647; DOI=10.1016/j.molp.2015.05.008;
RA Glass F., Haertel B., Zehrmann A., Verbitskiy D., Takenaka M.;
RT "MEF13 requires MORF3 and MORF8 for RNA editing at eight targets in
RT mitochondrial mRNAs in Arabidopsis thaliana.";
RL Mol. Plant 8:1466-1477(2015).
CC -!- FUNCTION: Involved in C-to-U editing of mitochondrial RNA. Required for
CC RNA editing at 8 sites in 6 different mRNAs in mitochondria.
CC {ECO:0000269|PubMed:26048647}.
CC -!- SUBUNIT: Interacts with MORF1/RIP8. {ECO:0000269|PubMed:26048647}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26048647}.
CC -!- DISRUPTION PHENOTYPE: Retarded growth, reduced size of leaves and
CC length of petioles. {ECO:0000269|PubMed:26048647}.
CC -!- SIMILARITY: Belongs to the PPR family. PCMP-E subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG12601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Pentatricopeptide repeat proteins;
CC URL="https://ppr.plantenergy.uwa.edu.au";
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DR EMBL; AC009755; AAF02108.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC068900; AAG12601.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73793.1; -; Genomic_DNA.
DR RefSeq; NP_186882.2; NM_111100.3.
DR AlphaFoldDB; Q9FWA6; -.
DR SMR; Q9FWA6; -.
DR BioGRID; 6448; 2.
DR STRING; 3702.AT3G02330.1; -.
DR PaxDb; Q9FWA6; -.
DR PRIDE; Q9FWA6; -.
DR ProteomicsDB; 249168; -.
DR EnsemblPlants; AT3G02330.1; AT3G02330.1; AT3G02330.
DR GeneID; 821115; -.
DR Gramene; AT3G02330.1; AT3G02330.1; AT3G02330.
DR KEGG; ath:AT3G02330; -.
DR Araport; AT3G02330; -.
DR TAIR; locus:2074562; AT3G02330.
DR eggNOG; KOG4197; Eukaryota.
DR HOGENOM; CLU_002706_15_6_1; -.
DR InParanoid; Q9FWA6; -.
DR OMA; NICVANA; -.
DR OrthoDB; 1344243at2759; -.
DR PhylomeDB; Q9FWA6; -.
DR PRO; PR:Q9FWA6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FWA6; baseline and differential.
DR Genevisible; Q9FWA6; AT.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0016554; P:cytidine to uridine editing; IMP:TAIR.
DR GO; GO:0080156; P:mitochondrial mRNA modification; IMP:TAIR.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 6.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF01535; PPR; 7.
DR Pfam; PF13041; PPR_2; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR00756; PPR; 7.
DR PROSITE; PS51375; PPR; 21.
PE 2: Evidence at transcript level;
KW Mitochondrion; mRNA processing; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 32..903
FT /note="Pentatricopeptide repeat-containing protein
FT At3g02330, mitochondrial"
FT /id="PRO_0000356066"
FT REPEAT 47..81
FT /note="PPR 1"
FT REPEAT 82..112
FT /note="PPR 2"
FT REPEAT 113..143
FT /note="PPR 3"
FT REPEAT 144..178
FT /note="PPR 4"
FT REPEAT 179..213
FT /note="PPR 5"
FT REPEAT 214..244
FT /note="PPR 6"
FT REPEAT 245..279
FT /note="PPR 7"
FT REPEAT 280..314
FT /note="PPR 8"
FT REPEAT 346..380
FT /note="PPR 9"
FT REPEAT 381..415
FT /note="PPR 10"
FT REPEAT 416..446
FT /note="PPR 11"
FT REPEAT 447..481
FT /note="PPR 12"
FT REPEAT 482..515
FT /note="PPR 13"
FT REPEAT 516..550
FT /note="PPR 14"
FT REPEAT 567..601
FT /note="PPR 15"
FT REPEAT 602..636
FT /note="PPR 16"
FT REPEAT 637..667
FT /note="PPR 17"
FT REPEAT 668..702
FT /note="PPR 18"
FT REPEAT 703..738
FT /note="PPR 19"
FT REPEAT 739..769
FT /note="PPR 20"
FT REGION 774..850
FT /note="Type E motif"
FT REGION 851..881
FT /note="Type E(+) motif"
SQ SEQUENCE 903 AA; 101714 MW; 7B8BC705649AD933 CRC64;
MAESLRLLHM TRSVVSFNRC LTEKISYRRV PSFSYFTDFL NQVNSVSTTN FSFVFKECAK
QGALELGKQA HAHMIISGFR PTTFVLNCLL QVYTNSRDFV SASMVFDKMP LRDVVSWNKM
INGYSKSNDM FKANSFFNMM PVRDVVSWNS MLSGYLQNGE SLKSIEVFVD MGREGIEFDG
RTFAIILKVC SFLEDTSLGM QIHGIVVRVG CDTDVVAASA LLDMYAKGKR FVESLRVFQG
IPEKNSVSWS AIIAGCVQNN LLSLALKFFK EMQKVNAGVS QSIYASVLRS CAALSELRLG
GQLHAHALKS DFAADGIVRT ATLDMYAKCD NMQDAQILFD NSENLNRQSY NAMITGYSQE
EHGFKALLLF HRLMSSGLGF DEISLSGVFR ACALVKGLSE GLQIYGLAIK SSLSLDVCVA
NAAIDMYGKC QALAEAFRVF DEMRRRDAVS WNAIIAAHEQ NGKGYETLFL FVSMLRSRIE
PDEFTFGSIL KACTGGSLGY GMEIHSSIVK SGMASNSSVG CSLIDMYSKC GMIEEAEKIH
SRFFQRANVS GTMEELEKMH NKRLQEMCVS WNSIISGYVM KEQSEDAQML FTRMMEMGIT
PDKFTYATVL DTCANLASAG LGKQIHAQVI KKELQSDVYI CSTLVDMYSK CGDLHDSRLM
FEKSLRRDFV TWNAMICGYA HHGKGEEAIQ LFERMILENI KPNHVTFISI LRACAHMGLI
DKGLEYFYMM KRDYGLDPQL PHYSNMVDIL GKSGKVKRAL ELIREMPFEA DDVIWRTLLG
VCTIHRNNVE VAEEATAALL RLDPQDSSAY TLLSNVYADA GMWEKVSDLR RNMRGFKLKK
EPGCSWVELK DELHVFLVGD KAHPRWEEIY EELGLIYSEM KPFDDSSFVR GVEVEEEDQW
CYC
