ATB12_ARATH
ID ATB12_ARATH Reviewed; 235 AA.
AC Q9M276; O64893;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-12;
DE AltName: Full=HD-ZIP protein ATHB-12;
DE AltName: Full=Homeodomain transcription factor ATHB-12;
GN Name=ATHB-12; OrderedLocusNames=At3g61890; ORFNames=F21F14.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=9617808; DOI=10.1023/a:1006084305012;
RA Lee Y.-H., Chun J.-Y.;
RT "A new homeodomain-leucine zipper gene from Arabidopsis thaliana induced by
RT water stress and abscisic acid treatment.";
RL Plant Mol. Biol. 37:377-384(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=11374882; DOI=10.1006/bbrc.2001.4904;
RA Lee Y.-H., Oh H.-S., Cheon C.-I., Hwang I.-T., Kim Y.-J., Chun J.-Y.;
RT "Structure and expression of the Arabidopsis thaliana homeobox gene Athb-
RT 12.";
RL Biochem. Biophys. Res. Commun. 284:133-141(2001).
RN [7]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=15369784; DOI=10.1016/j.bbrc.2004.08.127;
RA Shin D., Koo Y.D., Lee J., Lee H.-J., Baek D., Lee S., Cheon C.-I.,
RA Kwak S.-S., Lee S.Y., Yun D.-J.;
RT "Athb-12, a homeobox-leucine zipper domain protein from Arabidopsis
RT thaliana, increases salt tolerance in yeast by regulating sodium
RT exclusion.";
RL Biochem. Biophys. Res. Commun. 323:534-540(2004).
RN [8]
RP FUNCTION.
RX PubMed=15604708; DOI=10.1007/s11103-004-1581-4;
RA Olsson A.S.B., Engstroem P., Seoderman E.;
RT "The homeobox genes ATHB12 and ATHB7 encode potential regulators of growth
RT in response to water deficit in Arabidopsis.";
RL Plant Mol. Biol. 55:663-677(2004).
RN [9]
RP GENE FAMILY, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
RN [10]
RP INTERACTION WITH TFIIB1.
RX PubMed=24531799; DOI=10.1007/s00299-014-1576-9;
RA Capella M., Re D.A., Arce A.L., Chan R.L.;
RT "Plant homeodomain-leucine zipper I transcription factors exhibit different
RT functional AHA motifs that selectively interact with TBP or/and TFIIB.";
RL Plant Cell Rep. 33:955-967(2014).
CC -!- FUNCTION: Probable transcription activator that may act as growth
CC regulators in response to water deficit. {ECO:0000269|PubMed:11374882,
CC ECO:0000269|PubMed:15604708}.
CC -!- SUBUNIT: Interacts with TFIIB1. {ECO:0000269|PubMed:24531799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:15369784}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16055682,
CC ECO:0000269|PubMed:9617808}.
CC -!- INDUCTION: By water deficit, by abscisic acid (ABA), by cold and salt
CC stress. {ECO:0000269|PubMed:15369784, ECO:0000269|PubMed:16055682,
CC ECO:0000269|PubMed:9617808}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
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DR EMBL; AF001949; AAC39462.1; -; mRNA.
DR EMBL; AL138642; CAB71896.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80275.1; -; Genomic_DNA.
DR EMBL; AY059828; AAL24310.1; -; mRNA.
DR EMBL; BT002206; AAN72217.1; -; mRNA.
DR EMBL; AY087187; AAM64743.1; -; mRNA.
DR PIR; T47981; T47981.
DR PIR; T51751; T51751.
DR RefSeq; NP_191748.1; NM_116054.3.
DR AlphaFoldDB; Q9M276; -.
DR SMR; Q9M276; -.
DR BioGRID; 10676; 21.
DR STRING; 3702.AT3G61890.1; -.
DR PaxDb; Q9M276; -.
DR PRIDE; Q9M276; -.
DR ProteomicsDB; 246716; -.
DR EnsemblPlants; AT3G61890.1; AT3G61890.1; AT3G61890.
DR GeneID; 825362; -.
DR Gramene; AT3G61890.1; AT3G61890.1; AT3G61890.
DR KEGG; ath:AT3G61890; -.
DR Araport; AT3G61890; -.
DR TAIR; locus:2079542; AT3G61890.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_060842_3_0_1; -.
DR InParanoid; Q9M276; -.
DR OMA; DGQCCGD; -.
DR OrthoDB; 1130773at2759; -.
DR PhylomeDB; Q9M276; -.
DR PRO; PR:Q9M276; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M276; baseline and differential.
DR Genevisible; Q9M276; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR GO; GO:0006970; P:response to osmotic stress; IEP:TAIR.
DR GO; GO:0009615; P:response to virus; IEP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; PTHR24326; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..235
FT /note="Homeobox-leucine zipper protein ATHB-12"
FT /id="PRO_0000257793"
FT DNA_BIND 27..86
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 87..122
FT /note="Leucine-zipper"
FT REGION 128..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 35
FT /note="S -> N (in Ref. 1; AAC39462)"
FT /evidence="ECO:0000305"
FT CONFLICT 71..72
FT /note="VA -> MT (in Ref. 1; AAC39462)"
FT /evidence="ECO:0000305"
FT CONFLICT 184..187
FT /note="GFEE -> RVQG (in Ref. 1; AAC39462)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 27485 MW; 6A887E284B4D0689 CRC64;
MEEGDFFNCC FSEISSGMTM NKKKMKKSNN QKRFSEEQIK SLELIFESET RLEPRKKVQV
ARELGLQPRQ VAIWFQNKRA RWKTKQLEKE YNTLRANYNN LASQFEIMKK EKQSLVSELQ
RLNEEMQRPK EEKHHECCGD QGLALSSSTE SHNGKSEPEG RLDQGSVLCN DGDYNNNIKT
EYFGFEEETD HELMNIVEKA DDSCLTSSEN WGGFNSDSLL DQSSSNYPNW WEFWS
