ATB15_ARATH
ID ATB15_ARATH Reviewed; 836 AA.
AC Q9ZU11; Q5EE12; Q9FWZ0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-15;
DE AltName: Full=HD-ZIP protein ATHB-15;
DE AltName: Full=Homeodomain transcription factor ATHB-15;
DE AltName: Full=Protein CORONA;
DE AltName: Full=Protein INCURVATA 4;
GN Name=ATHB-15; Synonyms=CNA, ICU4; OrderedLocusNames=At1g52150;
GN ORFNames=F5F19.21, F9I5.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP MUTAGENESIS OF ALA-606.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=15705957; DOI=10.1105/tpc.104.026179;
RA Green K.A., Prigge M.J., Katzman R.B., Clark S.E.;
RT "CORONA, a member of the class III homeodomain leucine zipper gene family
RT in Arabidopsis, regulates stem cell specification and organogenesis.";
RL Plant Cell 17:691-704(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Ruzza V., Carabelli M., Ciarbelli A.R., Sessa G., Steindler C., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis ATHB-15 mRNA, encoding an HD-Zip
RT III protein related to ATHB-8.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=14701930; DOI=10.1093/pcp/pcg164;
RA Ohashi-Ito K., Fukuda H.;
RT "HD-zip III homeobox genes that include a novel member, ZeHB-13
RT (Zinnia)/ATHB-15 (Arabidopsis), are involved in procambium and xylem cell
RT differentiation.";
RL Plant Cell Physiol. 44:1350-1358(2003).
RN [7]
RP INDUCTION.
RX PubMed=16033795; DOI=10.1242/dev.01942;
RA Williams L., Grigg S.P., Xie M., Christensen S., Fletcher J.C.;
RT "Regulation of Arabidopsis shoot apical meristem and lateral organ
RT formation by microRNA miR166g and its AtHD-ZIP target genes.";
RL Development 132:3657-3668(2005).
RN [8]
RP FUNCTION.
RX PubMed=15598805; DOI=10.1105/tpc.104.026161;
RA Prigge M.J., Otsuga D., Alonso J.M., Ecker J.R., Drews G.N., Clark S.E.;
RT "Class III homeodomain-leucine zipper gene family members have overlapping,
RT antagonistic, and distinct roles in Arabidopsis development.";
RL Plant Cell 17:61-76(2005).
RN [9]
RP INDUCTION.
RX PubMed=15773855; DOI=10.1111/j.1365-313x.2005.02354.x;
RA Kim J., Jung J.-H., Reyes J.L., Kim Y.-S., Kim S.-Y., Chung K.-S.,
RA Kim J.A., Lee M., Lee Y., Kim V.N., Chua N.-H., Park C.-M.;
RT "microRNA-directed cleavage of ATHB15 mRNA regulates vascular development
RT in Arabidopsis inflorescence stems.";
RL Plant J. 42:84-94(2005).
RN [10]
RP GENE FAMILY.
RX PubMed=16805899; DOI=10.1111/j.1525-142x.2006.00107.x;
RA Prigge M.J., Clark S.E.;
RT "Evolution of the class III HD-Zip gene family in land plants.";
RL Evol. Dev. 8:350-361(2006).
RN [11]
RP FUNCTION, INDUCTION, AND MUTAGENESIS OF GLY-189.
RX PubMed=16617092; DOI=10.1104/pp.106.077149;
RA Ochando I., Jover-Gil S., Ripoll J.J., Candela H., Vera A., Ponce M.R.,
RA Martinez-Laborda A., Micol J.L.;
RT "Mutations in the microRNA complementarity site of the INCURVATA4 gene
RT perturb meristem function and adaxialize lateral organs in arabidopsis.";
RL Plant Physiol. 141:607-619(2006).
RN [12]
RP INTERACTION WITH ESR1 AND ESR2.
RX PubMed=17376809; DOI=10.1242/dev.001016;
RA Chandler J.W., Cole M., Flier A., Grewe B., Werr W.;
RT "The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly
RT control Arabidopsis embryo patterning via interaction with PHAVOLUTA.";
RL Development 134:1653-1662(2007).
RN [13]
RP INDUCTION.
RX PubMed=17237362; DOI=10.1093/pcp/pcm008;
RA Zhou G.-K., Kubo M., Zhong R., Demura T., Ye Z.-H.;
RT "Overexpression of miR165 affects apical meristem formation, organ polarity
RT establishment and vascular development in Arabidopsis.";
RL Plant Cell Physiol. 48:391-404(2007).
RN [14]
RP INTERACTION WITH ZPR3.
RX PubMed=18408069; DOI=10.1105/tpc.107.057448;
RA Kim Y.S., Kim S.G., Lee M., Lee I., Park H.Y., Seo P.J., Jung J.H.,
RA Kwon E.J., Suh S.W., Paek K.H., Park C.M.;
RT "HD-ZIP III activity is modulated by competitive inhibitors via a feedback
RT loop in Arabidopsis shoot apical meristem development.";
RL Plant Cell 20:920-933(2008).
RN [15]
RP GENE FAMILY.
RX PubMed=25263420; DOI=10.1016/j.ympev.2014.06.017;
RA Floyd S.K., Ryan J.G., Conway S.J., Brenner E., Burris K.P., Burris J.N.,
RA Chen T., Edger P.P., Graham S.W., Leebens-Mack J.H., Pires J.C.,
RA Rothfels C.J., Sigel E.M., Stevenson D.W., Neal Stewart C. Jr., Wong G.K.,
RA Bowman J.L.;
RT "Origin of a novel regulatory module by duplication and degeneration of an
RT ancient plant transcription factor.";
RL Mol. Phylogenet. Evol. 81:159-173(2014).
CC -!- FUNCTION: Probable transcription factor involved in the regulation of
CC meristem development to promote lateral organ formation. May regulates
CC procambial and vascular tissue formation or maintenance, and vascular
CC development in inflorescence stems. {ECO:0000269|PubMed:15598805,
CC ECO:0000269|PubMed:15705957, ECO:0000269|PubMed:16617092}.
CC -!- SUBUNIT: Interacts with ESR1 and ESR2 (PubMed:17376809). Interacts with
CC ZPR3 (PubMed:18408069). {ECO:0000269|PubMed:17376809,
CC ECO:0000269|PubMed:18408069}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9ZU11-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Highly expressed the developing vascular elements
CC and the adaxial portion of cotyledons. Expressed in developing ovules,
CC stamens and carpels. Expressed in procambium and shoot meristem.
CC {ECO:0000269|PubMed:14701930, ECO:0000269|PubMed:15705957}.
CC -!- INDUCTION: By auxin. Repressed by miR165 and miR166.
CC {ECO:0000269|PubMed:15773855, ECO:0000269|PubMed:16033795,
CC ECO:0000269|PubMed:16617092, ECO:0000269|PubMed:17237362}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class III subfamily.
CC {ECO:0000305}.
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DR EMBL; AY902309; AAW88440.1; -; Genomic_DNA.
DR EMBL; AJ439449; CAD28400.1; -; mRNA.
DR EMBL; AC006216; AAD12689.1; -; Genomic_DNA.
DR EMBL; AC022354; AAG26011.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32760.1; -; Genomic_DNA.
DR EMBL; AY060556; AAL31186.1; -; mRNA.
DR PIR; E96561; E96561.
DR RefSeq; NP_175627.1; NM_104096.3. [Q9ZU11-1]
DR AlphaFoldDB; Q9ZU11; -.
DR BioGRID; 26870; 2.
DR STRING; 3702.AT1G52150.2; -.
DR PaxDb; Q9ZU11; -.
DR PRIDE; Q9ZU11; -.
DR ProteomicsDB; 246718; -. [Q9ZU11-1]
DR EnsemblPlants; AT1G52150.1; AT1G52150.1; AT1G52150. [Q9ZU11-1]
DR GeneID; 841645; -.
DR Gramene; AT1G52150.1; AT1G52150.1; AT1G52150. [Q9ZU11-1]
DR KEGG; ath:AT1G52150; -.
DR Araport; AT1G52150; -.
DR eggNOG; ENOG502QPKR; Eukaryota.
DR HOGENOM; CLU_012517_0_0_1; -.
DR InParanoid; Q9ZU11; -.
DR PhylomeDB; Q9ZU11; -.
DR PRO; PR:Q9ZU11; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZU11; baseline and differential.
DR Genevisible; Q9ZU11; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044830; HD-Zip_III.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR013978; MEKHLA.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45950; PTHR45950; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF08670; MEKHLA; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Differentiation; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..836
FT /note="Homeobox-leucine zipper protein ATHB-15"
FT /id="PRO_0000331661"
FT DOMAIN 151..379
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 14..77
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT COILED 72..115
FT /evidence="ECO:0000255"
FT MUTAGEN 189
FT /note="G->D: In icu4-1 and icu4-2; gain of function.
FT Delayed in juvenile-to-adult and flowering phase change and
FT increased number of vegetative leaves, which lack abaxial
FT trichomes."
FT /evidence="ECO:0000269|PubMed:16617092"
FT MUTAGEN 606
FT /note="A->V: In cna-1; dominant negative. Loss of
FT organogenesis and formation of ring-like corona meristems."
FT /evidence="ECO:0000269|PubMed:15705957"
FT CONFLICT 181
FT /note="V -> I (in Ref. 1; AAW88440)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="E -> D (in Ref. 1; AAW88440)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="Q -> L (in Ref. 1; AAW88440)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="A -> T (in Ref. 1; AAW88440)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 836 AA; 91701 MW; 69D909C68C472C2B CRC64;
MAMSCKDGKL GCLDNGKYVR YTPEQVEALE RLYHDCPKPS SIRRQQLIRE CPILSNIEPK
QIKVWFQNRR CREKQRKEAS RLQAVNRKLT AMNKLLMEEN DRLQKQVSQL VHENSYFRQH
TPNPSLPAKD TSCESVVTSG QHQLASQNPQ RDASPAGLLS IAEETLAEFL SKATGTAVEW
VQMPGMKPGP DSIGIIAISH GCTGVAARAC GLVGLEPTRV AEIVKDRPSW FRECRAVEVM
NVLPTANGGT VELLYMQLYA PTTLAPPRDF WLLRYTSVLE DGSLVVCERS LKSTQNGPSM
PLVQNFVRAE MLSSGYLIRP CDGGGSIIHI VDHMDLEACS VPEVLRPLYE SPKVLAQKTT
MAALRQLKQI AQEVTQTNSS VNGWGRRPAA LRALSQRLSR GFNEAVNGFT DEGWSVIGDS
MDDVTITVNS SPDKLMGLNL TFANGFAPVS NVVLCAKASM LLQNVPPAIL LRFLREHRSE
WADNNIDAYL AAAVKVGPCS ARVGGFGGQV ILPLAHTIEH EEFMEVIKLE GLGHSPEDAI
VPRDIFLLQL CSGMDENAVG TCAELIFAPI DASFADDAPL LPSGFRIIPL DSAKEVSSPN
RTLDLASALE IGSAGTKAST DQSGNSTCAR SVMTIAFEFG IESHMQEHVA SMARQYVRGI
ISSVQRVALA LSPSHISSQV GLRTPLGTPE AQTLARWICQ SYRGYMGVEL LKSNSDGNES
ILKNLWHHTD AIICCSMKAL PVFTFANQAG LDMLETTLVA LQDISLEKIF DDNGRKTLCS
EFPQIMQQGF ACLQGGICLS SMGRPVSYER AVAWKVLNEE ENAHCICFVF INWSFV
