PP2C2_CAEEL
ID PP2C2_CAEEL Reviewed; 356 AA.
AC P49596;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable protein phosphatase 2C T23F11.1;
DE Short=PP2C;
DE EC=3.1.3.16;
GN Name=ppm-2; ORFNames=T23F11.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the PP2C family. {ECO:0000305}.
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DR EMBL; Z46343; CAA86456.2; -; Genomic_DNA.
DR PIR; E88434; E88434.
DR PIR; T25181; T25181.
DR RefSeq; NP_497949.1; NM_065548.5.
DR AlphaFoldDB; P49596; -.
DR SMR; P49596; -.
DR BioGRID; 40846; 6.
DR STRING; 6239.T23F11.1.2; -.
DR EPD; P49596; -.
DR PaxDb; P49596; -.
DR PeptideAtlas; P49596; -.
DR EnsemblMetazoa; T23F11.1.1; T23F11.1.1; WBGene00011953.
DR GeneID; 175610; -.
DR UCSC; T23F11.1.1; c. elegans.
DR CTD; 175610; -.
DR WormBase; T23F11.1; CE24009; WBGene00011953; ppm-2.
DR eggNOG; KOG0698; Eukaryota.
DR GeneTree; ENSGT00940000172210; -.
DR HOGENOM; CLU_013173_4_2_1; -.
DR InParanoid; P49596; -.
DR OMA; HKPNNEA; -.
DR OrthoDB; 957254at2759; -.
DR PhylomeDB; P49596; -.
DR PRO; PR:P49596; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00011953; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0048786; C:presynaptic active zone; IDA:WormBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:WormBase.
DR GO; GO:0030517; P:negative regulation of axon extension; IMP:WormBase.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IMP:WormBase.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; -; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase_dom.
DR PANTHER; PTHR13832; PTHR13832; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; SSF81606; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1..356
FT /note="Probable protein phosphatase 2C T23F11.1"
FT /id="PRO_0000057763"
FT DOMAIN 23..286
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT REGION 336..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 59
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 59
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 60
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 228
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 277
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 356 AA; 39064 MW; EDCB0841CFB026B5 CRC64;
MGQTLSEPVT KKESASCANE NYLVGSSCMQ GWRVDMEDAH THLLSLPDDP KCAFFAVYDG
HGGSKVSQYS GINLHKKVVA QKEFSEGNMK EAIEKGFLEL DQQMRVDEET KDDVSGTTAV
VVLIKEGDVY CGNAGDSRAV SSVVGEARPL SFDHKPSHET EARRIIAAGG WVEFNRVNGN
LALSRALGDF AFKNCDTKPA EEQIVTAFPD VITDKLTPDH EFIVLACDGI WDVMTNQEVV
DFVREKLAEK RDPQSICEEL LTRCLAPDCQ MGGLGCDNMT VVLVGLLHGQ SPDTLFTKCA
RPAVFTGVNN EDGDQNQIQQ DISRVINNFD GEQRVNAANQ EEEEDDNEPA PANFQV
