PP2D1_MOUSE
ID PP2D1_MOUSE Reviewed; 620 AA.
AC Q8BVT6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein phosphatase 2C-like domain-containing protein 1;
GN Name=Pp2d1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the PP2C family. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the protein phosphatase 2C family, it
CC lacks some of the conserved residues that bind manganese, suggesting it
CC has no phosphatase activity. {ECO:0000305}.
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DR EMBL; AK076579; BAC36402.1; -; mRNA.
DR CCDS; CCDS37653.1; -.
DR RefSeq; NP_775625.1; NM_173449.3.
DR AlphaFoldDB; Q8BVT6; -.
DR SMR; Q8BVT6; -.
DR STRING; 10090.ENSMUSP00000056682; -.
DR iPTMnet; Q8BVT6; -.
DR PhosphoSitePlus; Q8BVT6; -.
DR MaxQB; Q8BVT6; -.
DR PaxDb; Q8BVT6; -.
DR PRIDE; Q8BVT6; -.
DR ProteomicsDB; 291643; -.
DR Antibodypedia; 49756; 5 antibodies from 5 providers.
DR DNASU; 110332; -.
DR Ensembl; ENSMUST00000056198; ENSMUSP00000056682; ENSMUSG00000044957.
DR GeneID; 110332; -.
DR KEGG; mmu:110332; -.
DR UCSC; uc008czo.1; mouse.
DR CTD; 151649; -.
DR MGI; MGI:3612067; Pp2d1.
DR VEuPathDB; HostDB:ENSMUSG00000044957; -.
DR eggNOG; KOG0698; Eukaryota.
DR GeneTree; ENSGT00390000017863; -.
DR HOGENOM; CLU_023323_0_0_1; -.
DR InParanoid; Q8BVT6; -.
DR OMA; EHTTRNI; -.
DR OrthoDB; 364162at2759; -.
DR PhylomeDB; Q8BVT6; -.
DR TreeFam; TF332888; -.
DR BioGRID-ORCS; 110332; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Pp2d1; mouse.
DR PRO; PR:Q8BVT6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8BVT6; protein.
DR Bgee; ENSMUSG00000044957; Expressed in spermatid and 42 other tissues.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; -; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase_dom.
DR PANTHER; PTHR13832; PTHR13832; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; SSF81606; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..620
FT /note="Protein phosphatase 2C-like domain-containing
FT protein 1"
FT /id="PRO_0000320673"
FT DOMAIN 173..611
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
SQ SEQUENCE 620 AA; 70630 MW; BD6EE784449F7BE8 CRC64;
MNWELYSSPL RVFWRSKVWD EKTSTFTSDE NLKIGKMVGK RRRPRPKRSI DLEDSTEQLI
SGDMVTFPCS VCYRELNKAR NFLHKKHHNA LSMLGFQWMG GRQPKPKLVS LHRECIISNL
LRSSTYNEKV LHNVNYAFEF LWKKQVPSYF KLCDKVGETS TYSPNSNHLM IKGIAICSNN
NSAWKAEPNC KFTVVNDFGD KANVCFFGLF DSHYGYAAAD LASKEFQVLL LHQLSIQDPS
YQMTAEQKQL INSFDTVFRE EYRAREEAFS STYKTFRTSR REYEDTHKAF AKAFWRMDRL
LRLGRNETSR VRWSGCSALT CILEGGIKNP HANKDWEKTY QQGSTSLPFQ KTPQIISGVL
HLANAGNVQA VLCRNGKGFC LTKEHSTRNT KERRRVLYSE AVISSDDPYG LLDGHIKTTR
GLGFHGNLRL KKSIIPAPQT ISVPIDDLCQ FLILATNGLW QVLDKKEVTA LVITLFHAYK
ETHVPRPKSK PWPPIGLLSP PDSNIRVLFQ YQPENEDIMS TADGTKGLSD SIYAEAYTHQ
GTFSPKVTPY DPCSTKENSS LPTIDSKQEN EKELCIKNFY KGAAEYIGCE LVSAAIEGGS
RDSITVMVMF LNGSEYHRLT
