ATB53_ARATH
ID ATB53_ARATH Reviewed; 228 AA.
AC Q9LVR0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-53;
DE AltName: Full=HD-ZIP protein ATHB-53;
DE AltName: Full=Homeodomain transcription factor ATHB-53;
GN Name=ATHB-53; Synonyms=HB-8; OrderedLocusNames=At5g66700; ORFNames=MSN2.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, AND FUNCTION.
RX PubMed=15567172; DOI=10.1016/j.bbrc.2004.11.014;
RA Son O., Cho H.-Y., Kim M.-R., Lee H., Lee M.-S., Song E., Park J.H.,
RA Nam K.H., Chun J.-Y., Kim H.-J., Hong S.-K., Chung Y.-Y., Hur C.-G.,
RA Cho H.-T., Cheon C.-I.;
RT "Induction of a homeodomain-leucine zipper gene by auxin is inhibited by
RT cytokinin in Arabidopsis roots.";
RL Biochem. Biophys. Res. Commun. 326:203-209(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor that may play a regulatory role
CC in auxin/cytokinin signaling during root development.
CC {ECO:0000269|PubMed:15567172}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in root meristem, late flowers and
CC siliques. {ECO:0000269|PubMed:15567172, ECO:0000269|PubMed:16055682}.
CC -!- INDUCTION: By abscisic acid (ABA), by salt stress, by indole-3-acetic
CC acid (IAA) and during darkness conditions. Down-regulated by cytokinin.
CC {ECO:0000269|PubMed:15567172, ECO:0000269|PubMed:16055682}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
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DR EMBL; AY683477; AAV85903.1; -; mRNA.
DR EMBL; AB018119; BAA97276.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98253.1; -; Genomic_DNA.
DR EMBL; BT024847; ABD60730.1; -; mRNA.
DR RefSeq; NP_201471.1; NM_126068.3.
DR AlphaFoldDB; Q9LVR0; -.
DR SMR; Q9LVR0; -.
DR BioGRID; 22045; 6.
DR IntAct; Q9LVR0; 4.
DR STRING; 3702.AT5G66700.1; -.
DR PaxDb; Q9LVR0; -.
DR PRIDE; Q9LVR0; -.
DR ProteomicsDB; 246536; -.
DR EnsemblPlants; AT5G66700.1; AT5G66700.1; AT5G66700.
DR GeneID; 836803; -.
DR Gramene; AT5G66700.1; AT5G66700.1; AT5G66700.
DR KEGG; ath:AT5G66700; -.
DR Araport; AT5G66700; -.
DR TAIR; locus:2173669; AT5G66700.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_100008_1_0_1; -.
DR InParanoid; Q9LVR0; -.
DR OMA; PQNSHCI; -.
DR OrthoDB; 1260515at2759; -.
DR PhylomeDB; Q9LVR0; -.
DR PRO; PR:Q9LVR0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVR0; baseline and differential.
DR Genevisible; Q9LVR0; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR GO; GO:0048364; P:root development; TAS:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24326; PTHR24326; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..228
FT /note="Homeobox-leucine zipper protein ATHB-53"
FT /id="PRO_0000257804"
FT DNA_BIND 68..127
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 36..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..156
FT /note="Leucine-zipper"
SQ SEQUENCE 228 AA; 26392 MW; 5DED7F5C815D9F05 CRC64;
MDHGRLMDDQ MMLGSQVYPY TTQPQNSHCI IVNQIDGGEE SKPVKRRRKR RSKGSSATNE
EDVAEIGGML RKRKLTDEQV NMLEYSFGNE HKLESGRKEK IAGELGLDPR QVAVWFQNRR
ARWKNKKLEE EYAKLKNHHD NVVLGQCQLE SQILKLTEQL SEAQSEIRKL SERLEEMPTN
SSSSSLSVEA NNAPTDFELA PETNYNIPFY MLDNNYLQSM EYWDGLYV
