ID   PP3BB_XENLA             Reviewed;         271 AA.
AC   Q6GQ68;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3B-B;
GN   Name=ppp1r3b-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for phosphatase PP1.
CC       Facilitates interaction of the PP1 with enzymes of the glycogen
CC       metabolism and regulates its activity. Suppresses the rate at which PP1
CC       dephosphorylates (inactivates) glycogen phosphorylase and enhances the
CC       rate at which it activates glycogen synthase and therefore limits
CC       glycogen breakdown (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and
CC       PYGL. Associates with glycogen particles. Forms complexes with
CC       debranching enzyme, glycogen phosphorylase, glycogen synthase and
CC       phosphorylase kinase which is necessary for its regulation of PP1
CC       activity (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to PYGL. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072880; AAH72880.1; -; mRNA.
DR   RefSeq; NP_001085518.1; NM_001092049.1.
DR   AlphaFoldDB; Q6GQ68; -.
DR   SMR; Q6GQ68; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   DNASU; 443944; -.
DR   GeneID; 443944; -.
DR   KEGG; xla:443944; -.
DR   CTD; 443944; -.
DR   Xenbase; XB-GENE-6251522; ppp1r3b.S.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 443944; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0005981; P:regulation of glycogen catabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030682; PP1_3B.
DR   PANTHER; PTHR12307:SF13; PTHR12307:SF13; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome.
FT   CHAIN           1..271
FT                   /note="Protein phosphatase 1 regulatory subunit 3B-B"
FT                   /id="PRO_0000324548"
FT   DOMAIN          119..227
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT   MOTIF           56..59
FT                   /note="PP1-binding motif"
SQ   SEQUENCE   271 AA;  31269 MW;  2C29389EF083509D CRC64;
     MALDIAMKFY LRSPLRRDRV ECRITQSNEP LRPCIQTTDK TLLSELSNQE NKVKKRVSFA
     DSRGLALTMV KVYSDFDDEL EIPFNISELI DNIVNLTTVE KEHFVLDFVQ PSADYLDFRN
     RLKADSVCLE NCMLKDKALV GTVKVKNLAF QKCVKIRITF DSWQTYTDYD CQYVKDSYGG
     SDKDTFSFDV SLPDSIQSNA RLEFAVCFDC EGRIFWDSNK GLNYRIVRHG HRIPYDPVCV
     SVDQYGSPRC SYGIFPELPT YSGFDKLGPY Y