ATBP_DROGR
ID ATBP_DROGR Reviewed; 419 AA.
AC B4JND4;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=AT-rich binding protein {ECO:0000250|UniProtKB:Q86P48};
GN Name=ATbp {ECO:0000250|UniProtKB:Q86P48}; ORFNames=GH24797;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDV92227.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV92227.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: May be a transcription factor for genes having (A+T)
CC stretches in their promoter and/or enhancer regions. Binds to AT rich
CC DNA (By similarity). {ECO:0000250|UniProtKB:Q86P48}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86P48}.
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DR EMBL; CH916371; EDV92227.1; -; Genomic_DNA.
DR RefSeq; XP_001992520.1; XM_001992484.1.
DR AlphaFoldDB; B4JND4; -.
DR STRING; 7222.FBpp0158703; -.
DR EnsemblMetazoa; FBtr0160211; FBpp0158703; FBgn0132252.
DR GeneID; 6565897; -.
DR KEGG; dgr:6565897; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_712250_0_0_1; -.
DR InParanoid; B4JND4; -.
DR OMA; ERWYICD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B4JND4; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..419
FT /note="AT-rich binding protein"
FT /id="PRO_0000378613"
FT ZN_FING 29..52
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..376
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..405
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 121..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 44985 MW; C5C1A935A6F748D7 CRC64;
MGFPRILSKN HKIYTKLGEF CLSGDSFWIV CHTCQEELQT QDAFWKHIQD EHNFLHGVAK
QEHNRSSSSS YCLADVESAS AVTSNTTSVQ TAGNVTTVAV PVALYKYTED EQRDVAAAVE
LHEAQHQQQQ QQQQHQQQQQ QQQHQQQQQH QHHQHQQQQQ HLHQQQQQQQ QQQRDAAKEL
AELHAVAAAA AAAGGGGGDS SAHSSSIGGG IDIKVELTPE MQVAAAAAAA ASSNTTIYHL
SQVVPVSAPA PPPPPPTAAA ASSFLSGGAG SATAATIVGV STTATTTAAA AAAVTTVPQQ
SQLGSGNNAG AVMQQLGLPL IAVAQELAPK DSNSTTASAS SAVSSDDGER WYVCDYGTCG
IKFKYKSRME LHRVVHSKER RFNCDMCSAS FKQSCNLSTH RKKKHSLRGI KSDLLPQRF
