ID   ATBP_DROPS              Reviewed;         375 AA.
AC   B5DLV1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=AT-rich binding protein {ECO:0000250|UniProtKB:Q86P48};
GN   Name=ATbp {ECO:0000250|UniProtKB:Q86P48}; ORFNames=GA27554;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EDY72498.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: May be a transcription factor for genes having (A+T)
CC       stretches in their promoter and/or enhancer regions. Binds to AT rich
CC       DNA (By similarity). {ECO:0000250|UniProtKB:Q86P48}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86P48}.
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DR   EMBL; CH379064; EDY72498.1; -; Genomic_DNA.
DR   RefSeq; XP_002133871.1; XM_002133835.2.
DR   AlphaFoldDB; B5DLV1; -.
DR   SMR; B5DLV1; -.
DR   STRING; 7237.FBpp0284856; -.
DR   EnsemblMetazoa; FBtr0286418; FBpp0284856; FBgn0248919.
DR   GeneID; 6901170; -.
DR   KEGG; dpo:Dpse_GA27554; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_712250_0_0_1; -.
DR   InParanoid; B5DLV1; -.
DR   OMA; ERWYICD; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0248919; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..375
FT                   /note="AT-rich binding protein"
FT                   /id="PRO_0000378616"
FT   ZN_FING         29..52
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         308..332
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         338..361
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          110..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  40693 MW;  862BBA2502C81ACB CRC64;
     MGFPRILSKN NKIYTKLGEF CLSGDSFWIV CHTCQEELQT QDQFWKHIQD EHNFLHGVAK
     EHSRTSSYCL TDVEAAAATS GATTSQGAGS VTSVTVPLAL YHCSTKYSED DQREMDIHEA
     QQQQHQQQQQ HQQQQQLQQQ QQRDVAKELA ELHANAVAVA SAAAAAANES STRSSSGIDI
     KIEPPCLTLP PEMQAAAAAS NATIYHLPQL GPAAVPPPPP TTGFVSANVS TSTTVSTTPP
     NVTGSHSVMQ QQAGVLTGSG LSTLSMSVGP STAMAAALLS TQELPKDSNS TTASAGSAVS
     SDDGERWYIC DYETCGLKFK YKSRMELHRV VHSKERRFNC ELCSASFKQS CNLSTHRKKK
     HALRGIKSEI LPQRF