ID   PP4P2_XENTR             Reviewed;         276 AA.
AC   Q6DIE4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase;
DE            Short=Type 2 PtdIns-4,5-P2 4-Ptase;
DE            EC=3.1.3.78 {ECO:0000250|UniProtKB:Q8N4L2};
DE   AltName: Full=PtdIns-4,5-P2 4-Ptase II;
DE   AltName: Full=Transmembrane protein 55A;
GN   Name=pip4p2; Synonyms=tmem55a {ECO:0000250|UniProtKB:Q8N4L2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-
CC       bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate
CC       (PtdIns-4-P). {ECO:0000250|UniProtKB:Q8N4L2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795,
CC         ChEBI:CHEBI:58456; EC=3.1.3.78;
CC         Evidence={ECO:0000250|UniProtKB:Q8N4L2};
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q8N4L2}; Multi-pass membrane protein
CC       {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8N4L2}; Multi-
CC       pass membrane protein {ECO:0000255}.
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DR   EMBL; BC075598; AAH75598.1; -; mRNA.
DR   RefSeq; NP_001005000.1; NM_001005000.1.
DR   AlphaFoldDB; Q6DIE4; -.
DR   STRING; 8364.ENSXETP00000054935; -.
DR   PaxDb; Q6DIE4; -.
DR   DNASU; 448483; -.
DR   Ensembl; ENSXETT00000054935; ENSXETP00000054935; ENSXETG00000014598.
DR   GeneID; 448483; -.
DR   KEGG; xtr:448483; -.
DR   CTD; 55529; -.
DR   Xenbase; XB-GENE-951972; pip4p2.
DR   eggNOG; KOG4684; Eukaryota.
DR   HOGENOM; CLU_087485_0_0_1; -.
DR   InParanoid; Q6DIE4; -.
DR   OMA; CAYITIA; -.
DR   OrthoDB; 1346704at2759; -.
DR   PhylomeDB; Q6DIE4; -.
DR   TreeFam; TF316367; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014598; Expressed in 2-cell stage embryo and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0034597; F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
DR   InterPro; IPR019178; PtdIns-P2-Ptase.
DR   PANTHER; PTHR21014; PTHR21014; 1.
DR   Pfam; PF09788; Tmemb_55A; 2.
PE   2: Evidence at transcript level;
KW   Endosome; Hydrolase; Lipid metabolism; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..276
FT                   /note="Type 2 phosphatidylinositol 4,5-bisphosphate 4-
FT                   phosphatase"
FT                   /id="PRO_0000235232"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           106..112
FT                   /note="CX5R motif"
FT   COMPBIAS        12..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        106
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   276 AA;  30184 MW;  4C80A382061E8939 CRC64;
     MAADGIDERS PLISPSSGNV TPTAPPYLQQ NNLQAELPPP YTAIASPDAS GVPVINCRVC
     QSLINLDGKL HQHVVKCTVC NEATPIKTPP LGKKYVRCPC NCLLICKDIS RRIGCPRPNC
     RRIINLGPVM LIPEEQPAQP ALPVQPEGTR VVCGHCGNTF LWMELRFNTL AKCPHCKKMN
     CQVPRIQGKN GSAPGKAFRS SVGSALPRRR CCTYITMGMI CIFIGVGLTV GTQDFARRFH
     ATYVSWAVAY LVGLVCLIRA CYWGAIKFSY PEHSFA