PP4R1_MOUSE
ID PP4R1_MOUSE Reviewed; 951 AA.
AC Q8K2V1; Q8R0R8;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 1;
GN Name=Ppp4r1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4.
CC May play a role in regulation of cell division in renal glomeruli. The
CC PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and
CC regulation of HDAC3 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC different assemblies of the catalytic and one or more regulatory
CC subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with
CC HDAC3 (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2V1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2V1-2; Sequence=VSP_009470;
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DR EMBL; BC026489; AAH26489.1; -; mRNA.
DR EMBL; BC029761; AAH29761.1; -; mRNA.
DR CCDS; CCDS28941.2; -. [Q8K2V1-1]
DR RefSeq; NP_001107603.1; NM_001114131.1.
DR RefSeq; NP_666193.2; NM_146081.2.
DR RefSeq; XP_006524957.1; XM_006524894.3.
DR RefSeq; XP_006524958.1; XM_006524895.3. [Q8K2V1-2]
DR AlphaFoldDB; Q8K2V1; -.
DR BioGRID; 213994; 3.
DR ComplexPortal; CPX-157; PPP4C-PPP4R1 protein phosphatase 4 complex.
DR STRING; 10090.ENSMUSP00000072848; -.
DR iPTMnet; Q8K2V1; -.
DR PhosphoSitePlus; Q8K2V1; -.
DR EPD; Q8K2V1; -.
DR MaxQB; Q8K2V1; -.
DR PaxDb; Q8K2V1; -.
DR PeptideAtlas; Q8K2V1; -.
DR PRIDE; Q8K2V1; -.
DR ProteomicsDB; 289793; -. [Q8K2V1-1]
DR ProteomicsDB; 289794; -. [Q8K2V1-2]
DR DNASU; 70351; -.
DR GeneID; 70351; -.
DR KEGG; mmu:70351; -.
DR CTD; 9989; -.
DR MGI; MGI:1917601; Ppp4r1.
DR eggNOG; KOG0211; Eukaryota.
DR InParanoid; Q8K2V1; -.
DR OrthoDB; 249499at2759; -.
DR PhylomeDB; Q8K2V1; -.
DR BioGRID-ORCS; 70351; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Ppp4r1; mouse.
DR PRO; PR:Q8K2V1; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K2V1; protein.
DR GO; GO:0030289; C:protein phosphatase 4 complex; IEA:InterPro.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR031087; PP4R1.
DR PANTHER; PTHR10648:SF8; PTHR10648:SF8; 1.
DR Pfam; PF02985; HEAT; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..951
FT /note="Serine/threonine-protein phosphatase 4 regulatory
FT subunit 1"
FT /id="PRO_0000071528"
FT REPEAT 26..63
FT /note="HEAT 1"
FT REPEAT 65..81
FT /note="HEAT 2"
FT REPEAT 82..119
FT /note="HEAT 3"
FT REPEAT 127..164
FT /note="HEAT 4"
FT REPEAT 168..206
FT /note="HEAT 5"
FT REPEAT 208..246
FT /note="HEAT 6"
FT REPEAT 248..285
FT /note="HEAT 7"
FT REPEAT 287..324
FT /note="HEAT 8"
FT REPEAT 506..543
FT /note="HEAT 9"
FT REPEAT 699..735
FT /note="HEAT 10"
FT REPEAT 800..838
FT /note="HEAT 11"
FT REPEAT 862..899
FT /note="HEAT 12"
FT REGION 325..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 936
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TF05"
FT VAR_SEQ 1..349
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009470"
FT CONFLICT 353
FT /note="N -> S (in Ref. 1; AAH29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 375
FT /note="S -> P (in Ref. 1; AAH29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 529
FT /note="D -> E (in Ref. 1; AAH29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 585
FT /note="A -> V (in Ref. 1; AAH29761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 951 AA; 106298 MW; EE79740F81DE67C0 CRC64;
MADLSLLQED LPEDADGLDV DDYSSESDVI IIPSALDFVS QDEMLTPLGR LDKYAASENV
FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP TVRAELMEQV PHIALFCQEN
RPSIPYAFSK YLLPIVVRYL ADQNNQVRKT SQAALLALLE QELIERFDVE TKVCPVLIDL
TAPDSNDDVK TEAVAIMCKM APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI
CSVVGQQATE EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ CFKDESKSSE DSSAEDKDRM RDNDVVEEEH
RRPEDAPSDL SAPHSSARLE SLEGCAAKTP GHSAGDVPAP VDSSLLCTLS SESPQEAASN
DENGRKPDTN SKSASRPDAG TSSPEATPLD QDMFNSFHFW RTPLPKIDLD KELQQDPEER
LSPERTGDVP AAPLPGPPNI TMATRKELEE MIENLEPHMD DPDVKAQVDV LSAALRASSL
DAHEETGGVE QRSELQDEVC VSELPDCNIS HDTCVPLISA AEENAEATPD YVHGGADVSP
GDGFSPDEDR RPKVQDVVPQ ALLDQYLSMT DPSRAQTVDT EIAKHCAYSL PGVALTLGRQ
NWHCLRETYE TLASDMQWKV RRTLAFSIHE LAVILGDQLT AADLVPIFNG FLKDLDEVRI
GVLKHLHDFL KLLHIDKRRE YLYQLQEFLV TDNSRNWRFR AELAEQLILL LELYSPRDVY
DYLRPIALNL CADKVSSVRW ISYKLVSEMV KKLHTATPPT FGVDLINELV ENFGRCPKWS
GRQAFVFVCQ TVIEDDCLPM DQFAVHLMPH LLTLANDRVP NVRVLLAKTL RQTLLEKEYF
LASASCHQEA VEQTIMALQM DRDSDVKYFA SIHPSSTKLS EDAMSTASST Y
