ID   PP4R2_CANGA             Reviewed;         402 AA.
AC   Q6FUC3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 2;
DE            Short=PP4R2;
GN   Name=PSY4; OrderedLocusNames=CAGL0F04587g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulatory subunit of the histone H2A phosphatase complex,
CC       which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced
CC       from sites of DNA lesions in the double-stranded DNA break repair
CC       process. Dephosphorylation is necessary for efficient recovery from the
CC       DNA damage checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Regulatory subunit (R2) of the histone H2A phosphatase complex
CC       (HTP-C) consisting of PPH3, PSY2 and PSY4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PPP4R2 family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG59095.1; -; Genomic_DNA.
DR   RefSeq; XP_446171.1; XM_446171.1.
DR   AlphaFoldDB; Q6FUC3; -.
DR   SMR; Q6FUC3; -.
DR   STRING; 5478.XP_446171.1; -.
DR   EnsemblFungi; CAG59095; CAG59095; CAGL0F04587g.
DR   GeneID; 2887634; -.
DR   KEGG; cgr:CAGL0F04587g; -.
DR   CGD; CAL0129465; CAGL0F04587g.
DR   VEuPathDB; FungiDB:CAGL0F04587g; -.
DR   eggNOG; ENOG502S2WZ; Eukaryota.
DR   HOGENOM; CLU_685108_0_0_1; -.
DR   InParanoid; Q6FUC3; -.
DR   OMA; NMMGIKS; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   InterPro; IPR015267; PPP4R2.
DR   PANTHER; PTHR16487; PTHR16487; 1.
DR   Pfam; PF09184; PPP4R2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..402
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 2"
FT                   /id="PRO_0000223653"
FT   REGION          258..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..323
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  46539 MW;  1CA1945CA840AD65 CRC64;
     MDSASIDAIH MNGIKSKYLY DILKGIVREK NYDVLETINV SEFLAELLDH MVNTIPNELF
     QTKVNNGRHT VGRKEDSEEN EEAVYGTDID DANDVHTRQL DDLKRISTHL TTNFKDKSQL
     PFTIVRICEL CFDPFHYFKT YELDKFVNAL QKCCLVRGAW RRYELKDVRE LSNSQSDKEH
     IDCDQNDVAL SKIPWLDEKM VSELTPFIKE IDTIMSVNLS FEDDEMDDDD DDNLKNQNND
     RIITHQDDNI IVEEYYENED QDDENTGFSN QVINDNNDSQ EDDDEDSDYI EEDEGDEDED
     DDDDEEEEEE EDGDEDEDED KHFDIKVEEE AVKEDANTTR NELMNVSNNS DDSSLQNDTG
     IAISSQNDTR DLSKRRLPLS DENDGNYANP ASFSKRNKAS ES