ID   PP4R2_DICDI             Reviewed;         283 AA.
AC   Q86IL5; Q558S0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 2;
GN   Name=ppp4r2; Synonyms=ppr2; ORFNames=DDB_G0272668;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   FUNCTION, AND PROBABLE COMPONENT OF A COMPLEX WITH PPP4C.
RX   PubMed=17353263; DOI=10.1128/mcb.02194-06;
RA   Mendoza M.C., Booth E.O., Shaulsky G., Firtel R.A.;
RT   "MEK1 and protein phosphatase 4 coordinate Dictyostelium development and
RT   chemotaxis.";
RL   Mol. Cell. Biol. 27:3817-3827(2007).
CC   -!- FUNCTION: Probable regulatory subunit of serine/threonine-protein
CC       phosphatase 4 (PP4). {ECO:0000269|PubMed:17353263}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. Probably part of a PP4 complex containing ppp4c and ppp4r2.
CC   -!- SIMILARITY: Belongs to the PPP4R2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL70971.1; -; Genomic_DNA.
DR   RefSeq; XP_644996.1; XM_639904.1.
DR   AlphaFoldDB; Q86IL5; -.
DR   STRING; 44689.DDB0238106; -.
DR   PaxDb; Q86IL5; -.
DR   EnsemblProtists; EAL70971; EAL70971; DDB_G0272668.
DR   GeneID; 8618673; -.
DR   KEGG; ddi:DDB_G0272668; -.
DR   dictyBase; DDB_G0272668; ppr2.
DR   eggNOG; KOG3175; Eukaryota.
DR   HOGENOM; CLU_984923_0_0_1; -.
DR   InParanoid; Q86IL5; -.
DR   OMA; CYPWNIL; -.
DR   PhylomeDB; Q86IL5; -.
DR   PRO; PR:Q86IL5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IDA:dictyBase.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   InterPro; IPR015267; PPP4R2.
DR   PANTHER; PTHR16487; PTHR16487; 1.
DR   Pfam; PF09184; PPP4R2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..283
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 2"
FT                   /id="PRO_0000355973"
FT   REGION          75..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  31814 MW;  958EF6D5207324AF CRC64;
     MTLVEYSETL KKSLEEFCKQ DKKVVTPELN SIIENISKTG ITCYPWNILK ELFYFKLNEI
     LDIFEKEYIA TSSTTTTSTT TTTTNTSSSS TNSPQSPQSP QSPQLNVNIK DEEMQKIKNQ
     VNLSGLIKMK KEFLDSFKES KLSPFTVQRL CELIINYKMY TSFSKYLCAV EKMLNVSTLP
     HLTPEEVIEF NKNQNSGSRL NSSTNTTTTT TTTTTTTTPT EKGNNDQPNL DSFAFSSSFT
     TSFPSDTTSS TSTSLSTDQE MKDLDVEQQK DDTDNTANEN ESK