ID   ATB_ASPTN               Reviewed;         476 AA.
AC   Q0CJ61;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Efflux pump atB {ECO:0000303|PubMed:25265334};
DE   AltName: Full=Terreic acid biosynthesis cluster protein B {ECO:0000303|PubMed:25265334};
GN   Name=atB {ECO:0000303|PubMed:25265334}; ORFNames=ATEG_06273;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25265334; DOI=10.1021/ol502242a;
RA   Guo C.J., Sun W.W., Bruno K.S., Wang C.C.;
RT   "Molecular genetic characterization of terreic acid pathway in Aspergillus
RT   terreus.";
RL   Org. Lett. 16:5250-5253(2014).
CC   -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC       terreic acid (PubMed:25265334). {ECO:0000269|PubMed:25265334}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Greatly diminishes the production of terreic acid
CC       (PubMed:25265334). {ECO:0000269|PubMed:25265334}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000255}.
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DR   EMBL; CH476602; EAU32817.1; -; Genomic_DNA.
DR   RefSeq; XP_001215451.1; XM_001215451.1.
DR   AlphaFoldDB; Q0CJ61; -.
DR   PRIDE; Q0CJ61; -.
DR   EnsemblFungi; EAU32817; EAU32817; ATEG_06273.
DR   GeneID; 4322097; -.
DR   VEuPathDB; FungiDB:ATEG_06273; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   HOGENOM; CLU_008455_11_5_1; -.
DR   OMA; FIIWTIP; -.
DR   OrthoDB; 915468at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..476
FT                   /note="Efflux pump atB"
FT                   /id="PRO_0000437637"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  52855 MW;  16CCB74A8B86DC0F CRC64;
     MAPQLAGSSH SSSASDQAHR QSSDPALESG SDTHVGSIAP KTETDFLVSF TGDDDPRSPK
     HMSSARKWLI VAIVSSTRLG LSPMILAPLS EFYGRKPVYV VSMFFFVVWI IPCAVARNIE
     TLIVARFFNG FAGAAFLSVA GGTVGDLFPK NKLQAPMMVY TASPFLGPEL GPVIGNFINS
     YLDWRWSFYI LLIWAFAQWV SISLLVPETY HPVLLRREAQ RLRKETGDDR YYAPIEKMDR
     SIAQTIIRSC YRPFLLLTLE PMCLLLCLFC SVLLGVLYLF FGAFSLVFKD NHGFNLWQVG
     LSFLGITVGM IIGISTNPFW HRNFMRLLQN HEAKTGTVGS SEPEFRLPPA VGGAPLVTIG
     LLWFAWTTYP SVHWIVPIIG SGIFGAGVIM IFSGVFTFLV DAYPLYAASA LAANSFSRSM
     FAAAFPLFGQ AMFRNLGYQW AGFLLAMITL LLAPFPYIFY RWGAKIRQHS RYAGAK