ID   PP4R3_CANGA             Reviewed;         842 AA.
AC   Q6FR44;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3;
DE            Short=PP4R3;
GN   Name=PSY2; OrderedLocusNames=CAGL0I01056g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Core regulatory subunit of the histone H2A phosphatase
CC       complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been
CC       displaced from sites of DNA lesions in the double-stranded DNA break
CC       repair process. Dephosphorylation is necessary for efficient recovery
CC       from the DNA damage checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Regulatory subunit 3 (R3) of the histone H2A phosphatase
CC       complex (HTP-C) consisting of PPH3, PSY2 and PSY4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR380955; CAG60237.1; -; Genomic_DNA.
DR   RefSeq; XP_447300.1; XM_447300.1.
DR   AlphaFoldDB; Q6FR44; -.
DR   STRING; 5478.XP_447300.1; -.
DR   PRIDE; Q6FR44; -.
DR   EnsemblFungi; CAG60237; CAG60237; CAGL0I01056g.
DR   GeneID; 2888910; -.
DR   KEGG; cgr:CAGL0I01056g; -.
DR   CGD; CAL0132566; CAGL0I01056g.
DR   VEuPathDB; FungiDB:CAGL0I01056g; -.
DR   eggNOG; KOG2175; Eukaryota.
DR   HOGENOM; CLU_004909_4_0_1; -.
DR   InParanoid; Q6FR44; -.
DR   OMA; MMRGYML; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IEA:EnsemblFungi.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:EnsemblFungi.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:2000002; P:negative regulation of DNA damage checkpoint; IEA:EnsemblFungi.
DR   GO; GO:1902660; P:negative regulation of glucose mediated signaling pathway; IEA:EnsemblFungi.
DR   GO; GO:2001034; P:positive regulation of double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..842
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 3"
FT                   /id="PRO_0000223656"
SQ   SEQUENCE   842 AA;  96559 MW;  D83F1AAACAD2083A CRC64;
     MTLHSTNVTR TDSKRVKVYL LENNEWKDTG TGYCHGEVVS TELVDNKREE AFLLVTNENE
     PHQVLLRSKL EGNIEYQRQE ETLIVWKDVE GKDIALSFEE SLGCDTLCEF VVNVQRSIEP
     NISLVAVKSV DNGMGSIHEI ITGPVALPSI ETKQNTTTLL DALKILNDNT AFEYLKTETV
     EYVLKNNYID LLIAHFHKAE TEKIPRDLFL ISNILKTMIL YNQRDIIESL VEDKRIMGVV
     GILEYDTEFP TSKANHRKCL ESEAPSFKEI IPLENEELKT VIKKCFRLQF LKDVVLVQFL
     DDNNLGLITD IILDLETCII DSLQTDPFLD NLLQLYSKDK IYNSELTDES TDLIQKRKEG
     IKLLHQCIQM SRNLEHMDKS KFYKVLVKKG LFNLLDYAFN FEKDNNLRIL ATDTIIAIVE
     HDILLIHNVQ KEISQHNDRQ SLCLNGNQNE AKSSEANATV DLTLLEILST ILLTDNNPGL
     REQVVQALNT LLHPEGCIGD GFDNQLDNGL DFDDNILLRK DSNNLDDDFQ EQTGMSKIPP
     FTLNSSQQLE NQIAEYFKQF YIQIAPKLFG PLIENNCMSD EERQKYVNDD VLMIHLVKLV
     SFICSEHERL ISRKFVLENG ILDSISNLIN PGYRLQLRLT ALRCIKNIIC LDDKYYHRHM
     ISNELYSPIM KLMEEHLLED NLANSALQDF FRIIASECHV FKDDSELFNY SDNAYNINAT
     ELHRRSGSIP SSNFTMLNKH INDKYPEVLD KLLYITFVKQ LREQYKEHSK LLPNGKKRKI
     SADNVNDFDG DKINNGKKGQ LSKNKVMNYN SFETHIDDRA SSTDSQPATC LVGSPAAYDN
     AV