ID   PP4R3_TETNG             Reviewed;         818 AA.
AC   Q4S6U8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3;
DE   AltName: Full=SMEK homolog 1;
GN   Name=smek1; ORFNames=GSTENG00023117001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
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DR   EMBL; CAAE01014723; CAG03634.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4S6U8; -.
DR   STRING; 99883.ENSTNIP00000015261; -.
DR   KEGG; tng:GSTEN00023117G001; -.
DR   InParanoid; Q4S6U8; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..818
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 3"
FT                   /id="PRO_0000254601"
FT   DOMAIN          1..100
FT                   /note="WH1"
FT   REGION          718..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        721..780
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..804
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  93946 MW;  764169479D7610C1 CRC64;
     MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERFKGTSL LVRAESDGSL LLESKINPNT
     AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDVVDESEDE
     RFDDMSSPGL ELPPCELNRL EDLAELVASS LPSPLRREKL ALAVENEGYI RKLLDLFHVC
     EDLENREGLH HIYEIIKGIF LLNRTALFEV MFSDECIMDV IGCLEFDPAL PQPRRHREFL
     TKTAHFKEVI PISDPELRQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI
     VGMLQDDEKF LTDLFAQLTD EATDDDKRHE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM
     GILPALEVIL GMDDVQVRAA ATDIFSYLVE YNPSMVREFV MQESQQNDDD ILLINLIIEH
     MICDTDPELG GAVQLISLLR TLVDPENMLA TANKTEKTEF LSFFYKHCMH VLSAPLLANT
     TEDKPSKDDF QTSQLLALIL ELLTFCVEHH TYHIKNYIIN KDILRRVLVL TASKHAFLAL
     CALRFMRRII GLKDEFYNRY IMRNFLFEPV IKAFLNNGSR YNLMNSAIIE MFEYVRVEDV
     KSLTAHIVEN YWKALEDVDY VQTFKGLKLR YEQQRERQDN PKLDSMRSIL RNHRFRRDAR
     TLEDEEEMWF NTDEDDLEDG ETVVRTSDKI KTEEDLMEPI SKFMERKKLK EPEDKEILAK
     SSFSGRQNPS FKLAFSGSTK TSLSSPPPSA SLSPGSPGSP GSPGSGARSS PSNTSVTTKG
     GLVGLVDYPD DDEEEEDDDD EESKEEPLPP SKKSRLSS