ID   PP4R3_XENLA             Reviewed;         822 AA.
AC   Q6INN7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3;
DE   AltName: Full=SMEK homolog 1;
GN   Name=smek1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
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DR   EMBL; BC072239; AAH72239.1; -; mRNA.
DR   RefSeq; NP_001085057.1; NM_001091588.1.
DR   AlphaFoldDB; Q6INN7; -.
DR   PRIDE; Q6INN7; -.
DR   DNASU; 432127; -.
DR   GeneID; 432127; -.
DR   KEGG; xla:432127; -.
DR   CTD; 432127; -.
DR   Xenbase; XB-GENE-5858385; ppp4r3a.S.
DR   OMA; HFYENSA; -.
DR   OrthoDB; 388216at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 432127; Expressed in blastula and 19 other tissues.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..822
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 3"
FT                   /id="PRO_0000254602"
FT   DOMAIN          1..100
FT                   /note="WH1"
FT   REGION          744..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..781
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..808
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  94201 MW;  CF8735B5EF809B53 CRC64;
     MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINTNT
     AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDLVDESEEE
     RFDDMSSPGL ELPSCELSRL EEIAEVVASS LPSPLRREKL AVALENEGYL KKLLELFHVC
     EDLENIEGLH HLYEVIKGIF LLNRTALFEV MFSEDCMMDI IGCLEYDPSL PTQRKHREFL
     TKTAKFKEVI PISDPELKQK IHQTYRVQYI QDVVLPTPSV FEENMLSTLH SFIFFNKVEI
     VGMLQEDEKF LTELFAHLTD EATDDEKRQE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM
     GILPALEVIL GMDDPQVRSA ATDIFSYLVE YNPSMVREFV MQEAQQNDDD ILLINLIIEH
     MICDTDPELG GAVQLTGLLR TLVDPENMLA TTNKTEKTEF LGFFYKHCMH VLTAPLLANT
     TEEKPSKDDF QAAQLLALIL ELLTFCVEHH TYHIKNYIIN KDILRRVLVL MSSMHSFLGL
     CALRFMRKIV GLKDEFYNRY IVKSFLFEPV VKAFLNNGSR YNLMNSAILE IFEYIRVEDI
     KSLTAHVVEN YWKALEDVEY VQTFKGLKLR YDQQRERQDN PKLDSMRSIL RNHRYRRDAR
     SIEDEEEMWF NTDEDDLEDG EPVVLPSEKI KNSEDLMDPI SKFMERKKLK ESEEKEVLLK
     TNLTGRQSPN FKLSFSGATK TNLTSQLSAS GHPGSPGSPG SPGSPESPGS VSKSTPQAAA
     ITTKGGLIGL VDYPDDDEED DDNDEEEKEE RLPLTKKARL GS