ID   PP4R3_XENTR             Reviewed;         820 AA.
AC   Q6DFT3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3 {ECO:0000250|UniProtKB:Q5MIZ7};
DE   AltName: Full=SMEK homolog 2;
GN   Name=ppp4r3b {ECO:0000250|UniProtKB:Q5MIZ7}; Synonyms=smek2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4
CC       (PP4). {ECO:0000250}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC076650; AAH76650.1; -; mRNA.
DR   RefSeq; NP_001005004.1; NM_001005004.1.
DR   AlphaFoldDB; Q6DFT3; -.
DR   STRING; 8364.ENSXETP00000013375; -.
DR   PaxDb; Q6DFT3; -.
DR   GeneID; 448490; -.
DR   KEGG; xtr:448490; -.
DR   CTD; 57223; -.
DR   Xenbase; XB-GENE-1004661; ppp4r3b.
DR   eggNOG; KOG2175; Eukaryota.
DR   HOGENOM; CLU_004909_3_0_1; -.
DR   InParanoid; Q6DFT3; -.
DR   OMA; CESSGNM; -.
DR   OrthoDB; 388216at2759; -.
DR   PhylomeDB; Q6DFT3; -.
DR   TreeFam; TF315190; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006072; Expressed in ovary and 13 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IBA:GO_Central.
DR   GO; GO:0072542; F:protein phosphatase activator activity; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..820
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 3"
FT                   /id="PRO_0000254607"
FT   DOMAIN          1..100
FT                   /note="WH1"
FT   REGION          687..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        696..711
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  93716 MW;  2AA16C820E29A41C CRC64;
     MSDTRRRVKV YTLNEDRQWD DRGTGHVSST YVERLKGMSL LVRAESDGSL LLESKINPNT
     AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVEVT QDPIDESEEE
     RFEEMPETSN LIDLPTCELS KLEEIADLVT SVLSSPIRRE KLALALENEG YIKKLLQLFQ
     TCENLDNTEG LHHLYEIIRG ILFLNKAALF EVMFSDECIM DVVGCLEYDP ALAQPKRHRE
     FLTKTAKFKE VIPITDSELR QKIHQTYRVQ YIQDVILPTP SVFEENFLST LTSFIFFNKV
     EIVSMLQEDE KFLSEVFAQL TDEATDDDKR RELVNFFKEF CAFSQTLQPQ NRDAFFKTLA
     NLGILPALEI VMGMDDLQVR AAATDIFSYL VEFSPSMVRE FVMQEAQQSD DDILLINVVI
     EQMICDSDPE LGGAVQLMGL LRTLIDPENM LATANKTEKS EFLNFFYNHC MHVLTAPLLA
     NTSEDKLEKD AVLGSIKTST VCPDNYQTAQ LLALILELLT FCVEHHTYHI KNYIMNKDLL
     RRVLILMNSK HTFLALCALR FMRRIIGLKD EFYNRYIIKG NLFEPVINAL LDNGTRYNLL
     NSAIIELFEF IRVEDIKSLT SHIVENFYKA LESIEYVQTF KGLKTRYEQE KDRQSQKLSS
     VPSILRSNRF RRDARALEDD EELWFNEDEE EEGEAVVPPV EKTKTEDDFP EGYEKFLETK
     KAKELEDKEN LPKRTSVGGF KFTFSHSVSA ANGANSTNSK SVAAHTPPAS SNGSSSKNTS
     LTTTVASAKG SLIGLVDYPD DEDEEEEEDT SPRKRPRLGS