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PP4RL_HUMAN
ID   PP4RL_HUMAN             Reviewed;         415 AA.
AC   Q9P1A2; B4DRM4; Q96LY6; Q9BZ17; Q9BZ18;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 3.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like;
GN   Name=PPP4R1L; Synonyms=C20orf192; ORFNames=PRO1085;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 325-415 (ISOFORM 1).
RC   TISSUE=Fetal liver;
RA   Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.;
RT   "Functional prediction of the coding sequences of 79 new genes deduced by
RT   analysis of cDNA clones from human fetal liver.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a regulatory subunit of serine/threonine-protein
CC       phosphatase 4.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9P1A2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9P1A2-3; Sequence=VSP_056120;
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR   EMBL; AK057583; BAB71529.1; -; mRNA.
DR   EMBL; AK299330; BAG61336.1; -; mRNA.
DR   EMBL; AL035455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF119843; AAF69597.1; ALT_SEQ; mRNA.
DR   AlphaFoldDB; Q9P1A2; -.
DR   SMR; Q9P1A2; -.
DR   IntAct; Q9P1A2; 1.
DR   MINT; Q9P1A2; -.
DR   iPTMnet; Q9P1A2; -.
DR   PhosphoSitePlus; Q9P1A2; -.
DR   BioMuta; HGNC:15755; -.
DR   DMDM; 374095492; -.
DR   MassIVE; Q9P1A2; -.
DR   MaxQB; Q9P1A2; -.
DR   PaxDb; Q9P1A2; -.
DR   PeptideAtlas; Q9P1A2; -.
DR   PRIDE; Q9P1A2; -.
DR   ProteomicsDB; 77269; -.
DR   ProteomicsDB; 83640; -. [Q9P1A2-1]
DR   GeneCards; PPP4R1L; -.
DR   HGNC; HGNC:15755; PPP4R1L.
DR   neXtProt; NX_Q9P1A2; -.
DR   InParanoid; Q9P1A2; -.
DR   PhylomeDB; Q9P1A2; -.
DR   TreeFam; TF105560; -.
DR   PathwayCommons; Q9P1A2; -.
DR   ChiTaRS; PPP4R1L; human.
DR   Pharos; Q9P1A2; Tdark.
DR   PRO; PR:Q9P1A2; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9P1A2; protein.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR031088; PPP4R1L.
DR   PANTHER; PTHR10648:SF7; PTHR10648:SF7; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   5: Uncertain;
KW   Alternative splicing; Reference proteome; Repeat.
FT   CHAIN           1..415
FT                   /note="Putative serine/threonine-protein phosphatase 4
FT                   regulatory subunit 1-like"
FT                   /id="PRO_0000071530"
FT   REPEAT          86..124
FT                   /note="HEAT 1"
FT   REPEAT          163..202
FT                   /note="HEAT 2"
FT   REPEAT          203..241
FT                   /note="HEAT 3"
FT   REPEAT          242..280
FT                   /note="HEAT 4"
FT   REGION          301..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         2..144
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056120"
SQ   SEQUENCE   415 AA;  45908 MW;  F6E0FD9FDC1A2CFA CRC64;
     MAEIPLYFVD LQDDLDDYGF EDYGTDCDNM RVTAFLDIPG QDNLPPLTRL EKYAFSENTF
     NRQIIARGLL DIFRDFGNNE EDFLTVMEIV VRLSEDAEPT VRTELMEQIP PIAIFLQENR
     SNFPVVLSEY LIPIVVRYLT DPNNQIICKM ASMLSKSTVE RLLLPRFCEL CGDRKLFQVR
     KVCAANFGDI CHAVGQEATE KFLIPKFFEL CSDAVWGMRK ACAECFTAVS HSSSPGVRRT
     QLFPLFIRLV SDPCRWVHQA AFQSLGPFTS TFANPSRAGL YLREDGALSI WPLTQDLDSG
     FASGSPAPSS GGNTSPASLT RSAKPVRSEP ELPVEGTSAK TSDCPHSSSS SDGPAESPVE
     SCVSAGAEWT RVSPETSACS KLSDMNDLPI SSYPGSDSWA CPGNTEDVFS HFLYW
 
 
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