PP4RL_HUMAN
ID PP4RL_HUMAN Reviewed; 415 AA.
AC Q9P1A2; B4DRM4; Q96LY6; Q9BZ17; Q9BZ18;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like;
GN Name=PPP4R1L; Synonyms=C20orf192; ORFNames=PRO1085;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 325-415 (ISOFORM 1).
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.;
RT "Functional prediction of the coding sequences of 79 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a regulatory subunit of serine/threonine-protein
CC phosphatase 4.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P1A2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P1A2-3; Sequence=VSP_056120;
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057583; BAB71529.1; -; mRNA.
DR EMBL; AK299330; BAG61336.1; -; mRNA.
DR EMBL; AL035455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF119843; AAF69597.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q9P1A2; -.
DR SMR; Q9P1A2; -.
DR IntAct; Q9P1A2; 1.
DR MINT; Q9P1A2; -.
DR iPTMnet; Q9P1A2; -.
DR PhosphoSitePlus; Q9P1A2; -.
DR BioMuta; HGNC:15755; -.
DR DMDM; 374095492; -.
DR MassIVE; Q9P1A2; -.
DR MaxQB; Q9P1A2; -.
DR PaxDb; Q9P1A2; -.
DR PeptideAtlas; Q9P1A2; -.
DR PRIDE; Q9P1A2; -.
DR ProteomicsDB; 77269; -.
DR ProteomicsDB; 83640; -. [Q9P1A2-1]
DR GeneCards; PPP4R1L; -.
DR HGNC; HGNC:15755; PPP4R1L.
DR neXtProt; NX_Q9P1A2; -.
DR InParanoid; Q9P1A2; -.
DR PhylomeDB; Q9P1A2; -.
DR TreeFam; TF105560; -.
DR PathwayCommons; Q9P1A2; -.
DR ChiTaRS; PPP4R1L; human.
DR Pharos; Q9P1A2; Tdark.
DR PRO; PR:Q9P1A2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9P1A2; protein.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR031088; PPP4R1L.
DR PANTHER; PTHR10648:SF7; PTHR10648:SF7; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..415
FT /note="Putative serine/threonine-protein phosphatase 4
FT regulatory subunit 1-like"
FT /id="PRO_0000071530"
FT REPEAT 86..124
FT /note="HEAT 1"
FT REPEAT 163..202
FT /note="HEAT 2"
FT REPEAT 203..241
FT /note="HEAT 3"
FT REPEAT 242..280
FT /note="HEAT 4"
FT REGION 301..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 2..144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056120"
SQ SEQUENCE 415 AA; 45908 MW; F6E0FD9FDC1A2CFA CRC64;
MAEIPLYFVD LQDDLDDYGF EDYGTDCDNM RVTAFLDIPG QDNLPPLTRL EKYAFSENTF
NRQIIARGLL DIFRDFGNNE EDFLTVMEIV VRLSEDAEPT VRTELMEQIP PIAIFLQENR
SNFPVVLSEY LIPIVVRYLT DPNNQIICKM ASMLSKSTVE RLLLPRFCEL CGDRKLFQVR
KVCAANFGDI CHAVGQEATE KFLIPKFFEL CSDAVWGMRK ACAECFTAVS HSSSPGVRRT
QLFPLFIRLV SDPCRWVHQA AFQSLGPFTS TFANPSRAGL YLREDGALSI WPLTQDLDSG
FASGSPAPSS GGNTSPASLT RSAKPVRSEP ELPVEGTSAK TSDCPHSSSS SDGPAESPVE
SCVSAGAEWT RVSPETSACS KLSDMNDLPI SSYPGSDSWA CPGNTEDVFS HFLYW
