ID   PP6R3_CHICK             Reviewed;         873 AA.
AC   Q5F471;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Serine/threonine-protein phosphatase 6 regulatory subunit 3;
DE   AltName: Full=SAPS domain family member 3;
GN   Name=PPP6R3; Synonyms=PP6R3, SAPS3; ORFNames=RCJMB04_2j4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May
CC       function as a scaffolding PP6 subunit (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a
CC       heterotrimeric complex formed by the catalytic subunit, a SAPS domain-
CC       containing subunit (PP6R) and an ankyrin repeat-domain containing
CC       regulatory subunit (ARS). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAPS family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ851429; CAH65063.1; -; mRNA.
DR   RefSeq; NP_001026354.1; NM_001031183.1.
DR   AlphaFoldDB; Q5F471; -.
DR   STRING; 9031.ENSGALP00000032046; -.
DR   PaxDb; Q5F471; -.
DR   Ensembl; ENSGALT00000032683; ENSGALP00000032046; ENSGALG00000007037.
DR   GeneID; 423116; -.
DR   KEGG; gga:423116; -.
DR   CTD; 55291; -.
DR   VEuPathDB; HostDB:geneid_423116; -.
DR   eggNOG; KOG2073; Eukaryota.
DR   GeneTree; ENSGT00390000009899; -.
DR   HOGENOM; CLU_012598_0_1_1; -.
DR   InParanoid; Q5F471; -.
DR   OMA; NEMRHAD; -.
DR   OrthoDB; 329232at2759; -.
DR   PhylomeDB; Q5F471; -.
DR   TreeFam; TF313227; -.
DR   Reactome; R-GGA-204005; COPII-mediated vesicle transport.
DR   PRO; PR:Q5F471; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000007037; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q5F471; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007587; SAPS.
DR   PANTHER; PTHR12634; PTHR12634; 1.
DR   Pfam; PF04499; SAPS; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..873
FT                   /note="Serine/threonine-protein phosphatase 6 regulatory
FT                   subunit 3"
FT                   /id="PRO_0000046102"
FT   REGION          628..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          693..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          729..755
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          767..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        846..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  98310 MW;  A864119ED0BF0441 CRC64;
     MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK SECLEDLVSF
     IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QINDRLGEEE SLLMKLYSFL LNESPLNPLL
     ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLVIKHIGTS AIMDLLLRLL TCIEPPQPRQ
     EVLNWLNEER IIQRLVEIVH PSQDEDRHSN ASQSLCEIIR LSRDQMLQVQ NSSEPDPLLA
     SLEKREIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR QTFEGHIEIC PPGMSNSTYS
     VNKSVLEAIK ARLSSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS
     SVNQELIELN SIGVILDMFF KYTWNNFLHT QVEICIALIL ASPLESTENG TITDQDSTGD
     NLLLKHLFLK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSTL
     VQQLIKELPE EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS
     SLQQAFSDYQ MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL
     FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGTKQD
     LFESHANTED KMEVDLNEPP NWSANFDVPM ETAHGTNLDS VGSDVWSTEE PMPAKETGWA
     SFSEFTSSLS STDSLRSNSP VEMETNTEPM DPLSANATGL ATQLETPGSV AMEASSDGEE
     DAENADKVTE TVMNGSMKET LSLTVDAKTE TAVFKSEEGK LSTSQDASCK YVVEENAEVA
     EEAPSALQPA NSSPEQRTDQ RTLLGETSVN GPV