PP85_HCMVA
ID PP85_HCMVA Reviewed; 656 AA.
AC P16761; Q7M6Q8;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Phosphoprotein 85;
DE Short=pp85;
DE AltName: Full=Phosphoprotein UL25;
GN Name=UL25;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [3]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=10364360; DOI=10.1128/jvi.73.7.6073-6075.1999;
RA Zini N., Battista M.C., Santi S., Riccio M., Bergamini G., Landini M.P.,
RA Maraldi N.M.;
RT "The novel structural protein of human cytomegalovirus, pUL25, is localized
RT in the viral tegument.";
RL J. Virol. 73:6073-6075(1999).
RN [5]
RP IDENTIFICATION.
RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT HCMV proteome.";
RL J. Virol. 78:10960-10966(2004).
RN [6]
RP ERRATUM OF PUBMED:15452216.
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RL J. Virol. 78:13395-13395(2004).
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305|PubMed:10364360}.
CC Host cytoplasm {ECO:0000269|PubMed:10364360}. Note=Expressed
CC exclusively at the cytoplasmic level during the late phase of the virus
CC replication cycle. Also found in dense bodies.
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- MISCELLANEOUS: Major target antigen for the anti-CMV antibody response.
CC -!- SIMILARITY: Belongs to the herpesviridae pp85 family. {ECO:0000305}.
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DR EMBL; X17403; CAA35424.1; -; Genomic_DNA.
DR EMBL; BK000394; DAA00129.1; -; Genomic_DNA.
DR PIR; S09788; QQBET2.
DR RefSeq; YP_081484.1; NC_006273.2.
DR SMR; P16761; -.
DR PRIDE; P16761; -.
DR DNASU; 3077473; -.
DR GeneID; 3077473; -.
DR KEGG; vg:3077473; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR006731; Herpes_pp85.
DR Pfam; PF04637; Herpes_pp85; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Phosphoprotein; Reference proteome; Virion;
KW Virion tegument.
FT CHAIN 1..656
FT /note="Phosphoprotein 85"
FT /id="PRO_0000115314"
FT REGION 1..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73539 MW; 5A1AB5530FCA0BF8 CRC64;
MSSRRRSSSR RSGEPSTVIY IPSSNEDTPA DEEAEDSVFT STRARSATED LDRMEAGLSP
YSVSSDAPSS FELVRETGGT GAAKKPSEKK RSSSRRQPQI AAGAPRGSPA TPKAGKSPKV
SRPPSVPSLP ENGAGGGGDD NSSSGGSSSR TTSNSSRSTS PVAPGEPSAA EGDEFSFCDS
DIEDFERECY RVSVADNLGF EPSVVAPQHV EYLKFVLQDF DVQHLRRLNE CIPMPAFALT
SLVDPVLNNV APGERDLTRR IITHAVIINY YYVAQKKARH MVEAIRTTVR GDTVRRVAAQ
VNNQSRSGRA AALALHFLTS RKGVTDGQYA TSLRRLDEEL RHRGTPESPR LTEVYQTLRD
YNVLFYTAHY TSRGALYLYR QNLQRLNENH RGMLRLLSVE EICEEHTLND LAFLVGVELM
ITHFQRTIRV LRCYLQHQLQ SISELCYLIY VQLPSLREDY AQLSDVIYWA VSQNYDYALY
ASTPALFDFL RVVRQQDAFI CTDYVYCALR LLACPDRPII GDTGGSSSSQ RLVGEFMVRD
PLLRDPRATH LRQKLITRDI CVARLQAQPS SRHIPVEHTG VSSVTLLKIF SQVPPDEREE
DTLREMALKA FMEANGNHPE QICRSPPPPL PPRDYPQRDE RDRHRRDRRD SGEYCC
