ID   PP85_HCMVM              Reviewed;         656 AA.
AC   F5HGJ4;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 25.
DE   RecName: Full=Phosphoprotein 85;
DE            Short=pp85;
DE   AltName: Full=Phosphoprotein UL25;
GN   Name=UL25;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}. Host cytoplasm
CC       {ECO:0000250}. Note=Expressed exclusively at the cytoplasmic level
CC       during the late phase of the virus replication cycle. Also found in
CC       dense bodies (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Major target antigen for the anti-CMV antibody response.
CC   -!- SIMILARITY: Belongs to the herpesviridae pp85 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31590.1; -; Genomic_DNA.
DR   RefSeq; YP_081484.1; NC_006273.2.
DR   SMR; F5HGJ4; -.
DR   PRIDE; F5HGJ4; -.
DR   DNASU; 3077473; -.
DR   GeneID; 3077473; -.
DR   KEGG; vg:3077473; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR006731; Herpes_pp85.
DR   Pfam; PF04637; Herpes_pp85; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Phosphoprotein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..656
FT                   /note="Phosphoprotein 85"
FT                   /id="PRO_0000418310"
FT   REGION          1..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          615..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..656
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  73539 MW;  5A1AB5530FCA0BF8 CRC64;
     MSSRRRSSSR RSGEPSTVIY IPSSNEDTPA DEEAEDSVFT STRARSATED LDRMEAGLSP
     YSVSSDAPSS FELVRETGGT GAAKKPSEKK RSSSRRQPQI AAGAPRGSPA TPKAGKSPKV
     SRPPSVPSLP ENGAGGGGDD NSSSGGSSSR TTSNSSRSTS PVAPGEPSAA EGDEFSFCDS
     DIEDFERECY RVSVADNLGF EPSVVAPQHV EYLKFVLQDF DVQHLRRLNE CIPMPAFALT
     SLVDPVLNNV APGERDLTRR IITHAVIINY YYVAQKKARH MVEAIRTTVR GDTVRRVAAQ
     VNNQSRSGRA AALALHFLTS RKGVTDGQYA TSLRRLDEEL RHRGTPESPR LTEVYQTLRD
     YNVLFYTAHY TSRGALYLYR QNLQRLNENH RGMLRLLSVE EICEEHTLND LAFLVGVELM
     ITHFQRTIRV LRCYLQHQLQ SISELCYLIY VQLPSLREDY AQLSDVIYWA VSQNYDYALY
     ASTPALFDFL RVVRQQDAFI CTDYVYCALR LLACPDRPII GDTGGSSSSQ RLVGEFMVRD
     PLLRDPRATH LRQKLITRDI CVARLQAQPS SRHIPVEHTG VSSVTLLKIF SQVPPDEREE
     DTLREMALKA FMEANGNHPE QICRSPPPPL PPRDYPQRDE RDRHRRDRRD SGEYCC