ID   PP85_HHV6U              Reviewed;         609 AA.
AC   Q69549; Q69037;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 65.
DE   RecName: Full=Phosphoprotein 85;
DE            Short=pp85;
DE   AltName: Full=Protein U14;
GN   Name=U14; Synonyms=EFRF2;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm.
CC       Note=Expressed exclusively at the cytoplasmic level during the late
CC       phase of the virus replication cycle. Also found in dense bodies (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae pp85 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16719.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25528; AAA16719.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58393.1; -; Genomic_DNA.
DR   PIR; T09306; T09306.
DR   RefSeq; NP_042906.1; NC_001664.2.
DR   SMR; Q69549; -.
DR   PRIDE; Q69549; -.
DR   DNASU; 1487898; -.
DR   GeneID; 1487898; -.
DR   KEGG; vg:1487898; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006731; Herpes_pp85.
DR   Pfam; PF04637; Herpes_pp85; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Phosphoprotein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..609
FT                   /note="Phosphoprotein 85"
FT                   /id="PRO_0000342570"
FT   REGION          461..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  69560 MW;  7053B3F21CEFE66F CRC64;
     MVTHAMEEPK TFNIPTFVLD ENCNFIPEVL SRANAKYIKD VLIQDSYNTV CLANSFIPMT
     IQTAEQIMVI ITKFKFSRAR DLFEKVLRLG VHINRFYAGK KQVKHMITMM KSLFDTEEAM
     RRLDRALMGL FVDARGSSYM PLIALSLHEN GLPDSKFTKA VKLINTTLNS FHNRPDADIE
     QYAQKLRAYN YLYKIPHYTL KEAVDVYSEN LKDLSIGVNK KPTLLFTSSD DGYLSHIFND
     MLFLTSTWNM IYNCKVQIRR LTTWIKYEIN SIVEDCVLVG FQLPDLKDTI LDLAALTSNM
     NLVDPDKDLF SHYKLILEKL FEISIFATKA NICILPTFIK SHLIEFEDVL KRSNDDEDLN
     YLLLKSNDSD DEYDEDKLPI QVDPGRVDNV LTDSNFFNVT ADNAFSSIAI MPISYDKIID
     VEENVIQVLE VEMQSLSAVV YGAVANKYGL SLPQVIKRLN QNEGRASSRA SSSHSTSTIP
     YSPPQSGRST PTSILRQRAP IRSNSRSSSV SFSQDDDNRS HYSDETNISD YSYPMADLDL
     EDEEPMEDHP HSPQSASSNN SMSRRSRALQ NEQRRRTPTM APPSPARGQN NARLRRRTRR
     STETNDERL