ID   PPA1_PEDAC              Reviewed;          62 AA.
AC   P29430; P34912;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Bacteriocin pediocin PA-1;
DE   AltName: Full=Pediocin ACH;
DE   Flags: Precursor;
GN   Name=pedA; Synonyms=pap, papA;
OS   Pediococcus acidilactici.
OG   Plasmid pSRQ11, and Plasmid pSMB74.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Pediococcus; Pediococcus acidilactici group.
OX   NCBI_TaxID=1254;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAC-1.0; PLASMID=pSRQ11;
RX   PubMed=1514784; DOI=10.1128/aem.58.8.2360-2367.1992;
RA   Marugg J.D., Gonzalez C.F., Kunka B.S., Ledeboer A.M., Pucci M.J.,
RA   Toonen M.Y., Walker S.A., Zoetmulder L.C.M., Vandenbergh P.A.;
RT   "Cloning, expression, and nucleotide sequence of genes involved in
RT   production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici
RT   PAC1.0.";
RL   Appl. Environ. Microbiol. 58:2360-2367(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H; PLASMID=pSMB74;
RX   PubMed=7764941; DOI=10.1111/j.1472-765x.1994.tb00876.x;
RA   Motlagh A.M., Bukhtiyarova M.B., Ray B.R.;
RT   "Complete nucleotide sequence of pSMB 74, a plasmid encoding the production
RT   of pediocin AcH in Pediococcus acidilactici.";
RL   Lett. Appl. Microbiol. 18:305-312(1994).
RN   [3]
RP   PROTEIN SEQUENCE OF 19-62, AND DISULFIDE BONDS.
RC   STRAIN=PAC-1.0; PLASMID=pSRQ11;
RX   PubMed=1575516; DOI=10.1016/0003-9861(92)90480-k;
RA   Henderson J.T., Chopko A.L., van Wassenaar P.D.;
RT   "Purification and primary structure of pediocin PA-1 produced by
RT   Pediococcus acidilactici PAC-1.0.";
RL   Arch. Biochem. Biophys. 295:5-12(1992).
RN   [4]
RP   PROTEIN SEQUENCE OF 19-61.
RX   PubMed=1402795; DOI=10.1099/00221287-138-9-1985;
RA   Lozano J.C.N., Meyer J.N., Sletten K., Pelaz C., Nes I.F.;
RT   "Purification and amino acid sequence of a bacteriocin produced by
RT   Pediococcus acidilactici.";
RL   J. Gen. Microbiol. 138:1985-1990(1992).
CC   -!- FUNCTION: Bactericidal activity (effective inhibitor of
CC       L.monocytogenes).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000305}.
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DR   EMBL; M83924; AAA25559.1; -; Genomic_DNA.
DR   EMBL; M90679; AAA98337.1; -; Genomic_DNA.
DR   EMBL; U02482; AAC43293.1; -; Genomic_DNA.
DR   PIR; A48941; A48941.
DR   RefSeq; NP_857602.1; NC_004832.1.
DR   RefSeq; WP_002834575.1; NZ_SCHZ01000012.1.
DR   PDB; 5UKZ; NMR; -; A=19-62.
DR   PDB; 7VLY; EM; 2.45 A; A/E/H=19-62.
DR   PDBsum; 5UKZ; -.
DR   PDBsum; 7VLY; -.
DR   AlphaFoldDB; P29430; -.
DR   SMR; P29430; -.
DR   TCDB; 1.C.24.1.1; the pediocin (pediocin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023384; Bacteriocin_IIa_CS.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   InterPro; IPR010133; Bacteriocin_signal_seq.
DR   Pfam; PF01721; Bacteriocin_II; 1.
DR   TIGRFAMs; TIGR01847; bacteriocin_sig; 1.
DR   PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Bacteriocin;
KW   Direct protein sequencing; Disulfide bond; Plasmid; Secreted.
FT   PROPEP          1..18
FT                   /evidence="ECO:0000269|PubMed:1402795,
FT                   ECO:0000269|PubMed:1575516"
FT                   /id="PRO_0000002745"
FT   CHAIN           19..62
FT                   /note="Bacteriocin pediocin PA-1"
FT                   /id="PRO_0000002746"
FT   REGION          40..52
FT                   /note="Hydrophobic"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000269|PubMed:1575516"
FT   DISULFID        42..62
FT                   /evidence="ECO:0000269|PubMed:1575516"
FT   TURN            22..24
FT                   /evidence="ECO:0007829|PDB:5UKZ"
FT   STRAND          25..27
FT                   /evidence="ECO:0007829|PDB:5UKZ"
FT   STRAND          32..34
FT                   /evidence="ECO:0007829|PDB:5UKZ"
FT   HELIX           36..53
FT                   /evidence="ECO:0007829|PDB:7VLY"
FT   TURN            57..59
FT                   /evidence="ECO:0007829|PDB:5UKZ"
SQ   SEQUENCE   62 AA;  6644 MW;  8E6F10D49FA87BA9 CRC64;
     MKKIEKLTEK EMANIIGGKY YGNGVTCGKH SCSVDWGKAT TCIINNGAMA WATGGHQGNH
     KC