ID   PPA5_RABIT              Reviewed;         325 AA.
AC   O97860;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Tartrate-resistant acid phosphatase type 5;
DE            Short=TR-AP;
DE            EC=3.1.3.2;
DE   AltName: Full=Tartrate-resistant acid ATPase;
DE            Short=TrATPase;
DE   AltName: Full=Type 5 acid phosphatase;
DE   Flags: Precursor;
GN   Name=ACP5;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Japanese white; TISSUE=Bone;
RX   PubMed=9753427; DOI=10.1046/j.1365-2443.1998.00202.x;
RA   Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H.,
RA   Kawashima H.;
RT   "Large scale isolation of osteoclast-specific genes by an improved method
RT   involving the preparation of a subtracted cDNA library.";
RL   Genes Cells 3:459-475(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 2 iron ions. {ECO:0000250};
CC   -!- SUBUNIT: Exists either as monomer or, after proteolytic processing, as
CC       a dimer of two chains linked by disulfide bond(s). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
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DR   EMBL; AB009340; BAA75919.1; -; mRNA.
DR   RefSeq; NP_001075457.1; NM_001081988.1.
DR   AlphaFoldDB; O97860; -.
DR   SMR; O97860; -.
DR   GeneID; 100008599; -.
DR   KEGG; ocu:100008599; -.
DR   CTD; 54; -.
DR   InParanoid; O97860; -.
DR   OrthoDB; 711825at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008199; F:ferric iron binding; ISS:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; ISS:UniProtKB.
DR   CDD; cd07378; MPP_ACP5; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR024927; Acid_PPase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000898; Acid_Ptase_5; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Iron; Lysosome;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..325
FT                   /note="Tartrate-resistant acid phosphatase type 5"
FT                   /id="PRO_0000023983"
FT   CARBOHYD        116
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   325 AA;  36624 MW;  9AE28F2CDDCB5C7B CRC64;
     MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM
     LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ
     IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL
     ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH
     DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK
     EMTVTYMEAS GKSLFKTRLP KRAKA