PPAC_CHICK
ID PPAC_CHICK Reviewed; 158 AA.
AC Q5ZKG5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Low molecular weight phosphotyrosine protein phosphatase;
DE Short=LMW-PTP;
DE Short=LMW-PTPase;
DE EC=3.1.3.48;
DE AltName: Full=Low molecular weight cytosolic acid phosphatase;
DE EC=3.1.3.2;
GN Name=ACP1; ORFNames=RCJMB04_11a4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl
CC phosphates and natural and synthetic acyl phosphates. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein
CC phosphatase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720119; CAG31778.1; -; mRNA.
DR RefSeq; NP_001034380.1; NM_001039291.1.
DR AlphaFoldDB; Q5ZKG5; -.
DR SMR; Q5ZKG5; -.
DR BioGRID; 682668; 1.
DR STRING; 9031.ENSGALP00000026345; -.
DR PaxDb; Q5ZKG5; -.
DR Ensembl; ENSGALT00000085642; ENSGALP00000060364; ENSGALG00000016363.
DR GeneID; 421909; -.
DR KEGG; gga:421909; -.
DR CTD; 52; -.
DR VEuPathDB; HostDB:geneid_421909; -.
DR eggNOG; KOG3217; Eukaryota.
DR GeneTree; ENSGT00940000158351; -.
DR HOGENOM; CLU_071415_2_0_1; -.
DR InParanoid; Q5ZKG5; -.
DR OMA; TGSWHVG; -.
DR OrthoDB; 1362234at2759; -.
DR PhylomeDB; Q5ZKG5; -.
DR TreeFam; TF353727; -.
DR PRO; PR:Q5ZKG5; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000016363; Expressed in spermatid and 13 other tissues.
DR ExpressionAtlas; Q5ZKG5; baseline and differential.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR InterPro; IPR023485; Ptyr_pPase.
DR InterPro; IPR036196; Ptyr_pPase_sf.
DR InterPro; IPR002115; Tyr_Pase_low_mol_wt_mml.
DR InterPro; IPR017867; Tyr_phospatase_low_mol_wt.
DR Pfam; PF01451; LMWPc; 1.
DR PRINTS; PR00719; LMWPTPASE.
DR PRINTS; PR00720; MAMMALPTPASE.
DR SMART; SM00226; LMWPc; 1.
DR SUPFAM; SSF52788; SSF52788; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Hydrolase; Phosphoprotein; Protein phosphatase;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..158
FT /note="Low molecular weight phosphotyrosine protein
FT phosphatase"
FT /id="PRO_0000256846"
FT ACT_SITE 13
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:P11064"
FT ACT_SITE 19
FT /evidence="ECO:0000250|UniProtKB:P11064"
FT ACT_SITE 130
FT /note="Proton donor"
FT /evidence="ECO:0000250|UniProtKB:P11064"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
FT MOD_RES 132
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250"
FT MOD_RES 133
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 158 AA; 18196 MW; 8BC36CCA25984EB6 CRC64;
MAAGEVKSVL FVCLGNICRS PIAEAVFRKL VTDEKVENKW RIDSAATSTY EIGNPPDYRG
QTCMKKHGIT MNHIARQVTK DDFQTFDYIL CMDESNLRDL KRKSNQVKDC KAKIELLGAY
DPQKQLIIED PYYGNEKDFE TVYEQCVRCC KAFLEKPH
