PPAN_DROME
ID PPAN_DROME Reviewed; 460 AA.
AC Q9VDE5; O97133;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein Peter pan;
GN Name=ppan; ORFNames=CG5786;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=10359593; DOI=10.1091/mbc.10.6.1733;
RA Migeon J.C., Garfinkel M.S., Edgar B.A.;
RT "Cloning and characterization of peter pan, a novel Drosophila gene
RT required for larval growth.";
RL Mol. Biol. Cell 10:1733-1744(1999).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237; SER-239; THR-353 AND
RP SER-355, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for initiation of larval growth and normal mitotic
CC growth but is not absolutely required for general biosynthesis or DNA
CC replication. Required for progression of normal oogenesis and
CC maturation of some imaginal tissues into adult structures.
CC {ECO:0000269|PubMed:10359593}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10359593}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, highest
CC expression level is during embryogenesis.
CC {ECO:0000269|PubMed:10359593}.
CC -!- SIMILARITY: Belongs to the PPAN family. {ECO:0000305}.
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DR EMBL; AF102805; AAD16459.1; -; mRNA.
DR EMBL; AE014297; AAF55851.1; -; Genomic_DNA.
DR RefSeq; NP_476979.1; NM_057631.6.
DR AlphaFoldDB; Q9VDE5; -.
DR SMR; Q9VDE5; -.
DR BioGRID; 67473; 4.
DR IntAct; Q9VDE5; 1.
DR STRING; 7227.FBpp0083415; -.
DR iPTMnet; Q9VDE5; -.
DR PaxDb; Q9VDE5; -.
DR PRIDE; Q9VDE5; -.
DR EnsemblMetazoa; FBtr0084012; FBpp0083415; FBgn0010770.
DR GeneID; 42502; -.
DR KEGG; dme:Dmel_CG5786; -.
DR CTD; 56342; -.
DR FlyBase; FBgn0010770; ppan.
DR VEuPathDB; VectorBase:FBgn0010770; -.
DR eggNOG; KOG2963; Eukaryota.
DR GeneTree; ENSGT00530000064158; -.
DR HOGENOM; CLU_026936_0_0_1; -.
DR InParanoid; Q9VDE5; -.
DR OMA; MWHEYIH; -.
DR OrthoDB; 1199197at2759; -.
DR PhylomeDB; Q9VDE5; -.
DR BioGRID-ORCS; 42502; 1 hit in 3 CRISPR screens.
DR ChiTaRS; ppan; fly.
DR GenomeRNAi; 42502; -.
DR PRO; PR:Q9VDE5; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0010770; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR ExpressionAtlas; Q9VDE5; baseline and differential.
DR Genevisible; Q9VDE5; DM.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0007292; P:female gamete generation; IMP:UniProtKB.
DR GO; GO:0007444; P:imaginal disc development; IMP:UniProtKB.
DR GO; GO:0002164; P:larval development; IMP:UniProtKB.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR045112; PPAN-like.
DR PANTHER; PTHR12661; PTHR12661; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Differentiation; Oogenesis;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..460
FT /note="Protein Peter pan"
FT /id="PRO_0000120246"
FT DOMAIN 28..290
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 315..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..350
FT /evidence="ECO:0000255"
FT COMPBIAS 315..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..370
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 237
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 239
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 353
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT CONFLICT 70
FT /note="K -> Q (in Ref. 1; AAD16459)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="S -> C (in Ref. 1; AAD16459)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="R -> G (in Ref. 1; AAD16459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 53093 MW; BA35F43BBF291EF6 CRC64;
MGGKKKVHPK TRTAAFKASE PSEIVEAPHS FVIHRGLACP YITDLTLDFR RIMEPFTASN
LREKRMNRIK DFVSLSSFFH VSHMGIFNKA STQLSFKVVR LPRGPSLTFK VHQFTLARDV
ISLSKKQMID NDHFKHAPLV IMNNFSGDGK HLKLMATTFQ NMFPSINLAT VNIGTIRRCV
LFSYNPDTKL VEMRHYSVQV VPVGLKRAVQ KIVKGTVPNL GKCNEVVDFV TKDGYASESE
AEDDEQSHVV LAQTLKSKGN LEDKKSSIKL HEIGPRLTMQ LIKIEEGLLT GEVLYHDHVV
KTEDEKETLR KLVEKKRKQK EQRKKEQAEN RARNLKLKKD EKWAAKRAAE GRTDSDPEDD
AEYYKEEVGE EPDEELFKME AKSSRKRPSL GGGMKYKNKR AKLDTKDKND KSERTDKYDR
KDKFDRKDKK DKFDPKNRRA KFDPKNKRAK FDHRKSRKSK
