ID   PPARA_XENLA             Reviewed;         474 AA.
AC   P37232;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Peroxisome proliferator-activated receptor alpha;
DE            Short=PPAR-alpha;
DE   AltName: Full=Nuclear receptor subfamily 1 group C member 1;
GN   Name=ppara; Synonyms=nr1c1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1312391; DOI=10.1016/0092-8674(92)90031-7;
RA   Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.;
RT   "Control of the peroxisomal beta-oxidation pathway by a novel family of
RT   nuclear hormone receptors.";
RL   Cell 68:879-887(1992).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8274443; DOI=10.1016/0960-0760(93)90058-5;
RA   Krey G., Keller H., Mahfoudi A., Medin J., Ozato K., Dreyer C., Wahli W.;
RT   "Xenopus peroxisome proliferator activated receptors: genomic organization,
RT   response element recognition, heterodimer formation with retinoid X
RT   receptor and activation by fatty acids.";
RL   J. Steroid Biochem. Mol. Biol. 47:65-73(1993).
CC   -!- FUNCTION: Ligand-activated transcription factor. Key regulator of lipid
CC       metabolism. Activated by lipids. Receptor for peroxisome proliferators
CC       such as hypolipidemic drugs and fatty acids. Once activated by a
CC       ligand, the receptor binds to promoter elements of target genes.
CC       Regulates the peroxisomal beta-oxidation pathway of fatty acids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- DEVELOPMENTAL STAGE: Oocytes, embryos, and adults.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M84161; AAA49935.1; -; mRNA.
DR   PIR; A42214; A42214.
DR   AlphaFoldDB; P37232; -.
DR   SMR; P37232; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR003074; 1Cnucl_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR003076; PPAR-alpha.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01289; PROXISOMPAAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..474
FT                   /note="Peroxisome proliferator-activated receptor alpha"
FT                   /id="PRO_0000053485"
FT   DOMAIN          245..472
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        106..180
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         109..129
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         146..168
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   474 AA;  52856 MW;  4DBB941318D43483 CRC64;
     MSTIMVDTNS ELCILTPLDE DDLESPLSGE FLQDIVDIQD ITQTIGDDGS TPFGASEHQF
     FGNSPGSIGS VSTDLTDTLS PASSPASITF PAASGSAEDA ACKSLNLECR VCSDKASGFH
     YGVHACEGCK GFFRRTIRLK LVYDRCERMC KIQKKNRNKC QYCRFEKCLN VGMSHNAIRF
     GRMPRSEKAK LKAEVLMCDQ DVKDSQMADL LSLARLIYDA YLKNFNMNKV KARAILTGKA
     SNPPFVIHDM ETLCMAEKTL VAKLVANGIQ NKEAEVRIFH CCQCTSVETV TELTEFAKSI
     PGFTELDLND QVTLLKYGVY EAMFAMLASV MNKDGMLVAY GNGFITREFL KSLRKPIGDM
     MEPKFEFAMK FNALELDDSD LSLFVAALIC CGDRPGLVNI PSIEKMQESI VHVLKLHLQS
     NHPDDSFLFP KLLQKMADLR QLVTEHAQLV QTIKKTETDA ALHPLLQEIY RDMY