ID   PPARD_XENLA             Reviewed;         396 AA.
AC   P37233;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Peroxisome proliferator-activated receptor delta;
DE            Short=PPAR-delta;
DE   AltName: Full=Nuclear receptor subfamily 1 group C member 2;
DE   AltName: Full=Peroxisome proliferator-activated receptor beta;
DE            Short=PPAR-beta;
GN   Name=ppard; Synonyms=nr1c2, pparb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1312391; DOI=10.1016/0092-8674(92)90031-7;
RA   Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.;
RT   "Control of the peroxisomal beta-oxidation pathway by a novel family of
RT   nuclear hormone receptors.";
RL   Cell 68:879-887(1992).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8274443; DOI=10.1016/0960-0760(93)90058-5;
RA   Krey G., Keller H., Mahfoudi A., Medin J., Ozato K., Dreyer C., Wahli W.;
RT   "Xenopus peroxisome proliferator activated receptors: genomic organization,
RT   response element recognition, heterodimer formation with retinoid X
RT   receptor and activation by fatty acids.";
RL   J. Steroid Biochem. Mol. Biol. 47:65-73(1993).
CC   -!- FUNCTION: Ligand-activated transcription factor. Receptor that binds
CC       peroxisome proliferators such as hypolipidemic drugs and fatty acids.
CC       Has a preference for poly-unsaturated fatty acids, such as gamma-
CC       linoleic acid and eicosapentanoic acid. Once activated by a ligand, the
CC       receptor binds to promoter elements of target genes. Regulates the
CC       peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- DEVELOPMENTAL STAGE: Oocytes, embryos, and adults.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M84162; AAA49936.1; -; mRNA.
DR   PIR; B42214; B42214.
DR   RefSeq; NP_001081310.1; NM_001087841.1.
DR   AlphaFoldDB; P37233; -.
DR   SMR; P37233; -.
DR   GeneID; 397768; -.
DR   KEGG; xla:397768; -.
DR   CTD; 397768; -.
DR   Xenbase; XB-GENE-865134; ppard.S.
DR   OrthoDB; 583704at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 397768; Expressed in lung and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR003074; 1Cnucl_rcpt.
DR   InterPro; IPR003075; 1Cnucl_rcpt_B.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01290; PROXISOMPABR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..396
FT                   /note="Peroxisome proliferator-activated receptor delta"
FT                   /id="PRO_0000053488"
FT   DOMAIN          166..394
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        28..102
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         31..51
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         68..90
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  44992 MW;  D2F626BE07EBD750 CRC64;
     MKEEIPPRSP ILDEQPSTPL EHQETSQSVD CKICGDRASG FHYGVHACEG CKGFFRRTIR
     MRLQYEHCDR NCKIQKKNRN KCQYCRFNKC LSLGMSHNAI RFGRMPESEK RKLVQAPVSD
     SAAPDSPVSD LDVLSQLIHS SYMNTFTMTK KRARDILTGR NSISPFVIHD MDTLWQAEQG
     TVWEQLPTQN LTGTEIGVHV FYRCQCTSVE TVRALTDFAK RIPGFGTLYL NDQVTLLKYG
     VHEAIFCMLA SLMNKDGLLV AGGRGFVTRE FLRSLRQPFC HIMEPKFHFA SKFNALELND
     SDLALFVASI ILCGDRPGLI NPSQVEDIQE GILGALRRHL KASHTDAPFL FPKLLHKMAD
     LRQLVTEHAE LVQSIKRTES SAALHPLLQE IYRDMY